DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
DSGSCLS
Uniprot ID:
P35368
Source protein:
Alpha-1B adrenergic receptor
Source gene:
ADRA1B
Class:
DEG_SCF_TRCP1_1
Location:
409:415
E3 ligase:
BTRC
DEGRON score:
0.9892
ASA_SCORE:
81.2286
COIL:
0.8579
CONS_SCORE:
0.298
DSS_SCORE:
0.6231
HELIX:
0.058
FCONS_SCORE:
0.9709
RIG_SCORE:
0.6222
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.S425L
DO856
BLCA
ICGC
DSGSCLS
DEG_SCF_TRCP1_1
0.0556
p.D409N
ACH-001389
Breast Cancer
CCLE
DSGSCLS
DEG_SCF_TRCP1_1
0.6932
Drug responses associated with ADRA1B mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DSGSCLS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P35368
Alpha-1B adrenergic receptor
DEG_SCF_TRCP1_1
409:415
DSGSCLS
BTRC
0.9892
More...