DegronMD

Uniprot ID: O95251

Source protein: Histone acetyltransferase KAT7

Source gene: KAT7

Class: DEG_SCF_TRCP1_1

Location: 161:167

E3 ligase: BTRC

DEGRON score: 0.9674

ASA_SCORE: 77.7429

COIL: 0.8184

CONS_SCORE: 0.3113

DSS_SCORE: 0.613

HELIX: 0.1506

FCONS_SCORE: 0.9473

RIG_SCORE: 0.6002

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R172H	TCGA-AG-3892	READ	TCGA	DSGSDLS	DEG_SCF_TRCP1_1	0.1944
p.R172H	TCGA-AJ-A3EK	UCEC	TCGA	DSGSDLS	DEG_SCF_TRCP1_1	0.1944
p.R172H	DO36394	READ	ICGC	DSGSDLS	DEG_SCF_TRCP1_1	0.1944
p.R172H	DO41584	UCEC	ICGC	DSGSDLS	DEG_SCF_TRCP1_1	0.1944
p.R172H	SIDM01588	Endometrial Carcinoma	GDSC	DSGSDLS	DEG_SCF_TRCP1_1	0.1944
p.R172H	ACH-000993	Endometrial/Uterine Cancer	CCLE	DSGSDLS	DEG_SCF_TRCP1_1	0.1944
p.R174H	TCGA-AP-A1DV	UCEC	TCGA	DSGSDLS	DEG_SCF_TRCP1_1	0.1389
p.R174H	TCGA-B5-A3FC	UCEC	TCGA	DSGSDLS	DEG_SCF_TRCP1_1	0.1389
p.R174H	DO43186	UCEC	ICGC	DSGSDLS	DEG_SCF_TRCP1_1	0.1389
p.R174H	DO41871	UCEC	ICGC	DSGSDLS	DEG_SCF_TRCP1_1	0.1389
p.R174H	SIDM00145	T-Lymphoblastic Leukemia	GDSC	DSGSDLS	DEG_SCF_TRCP1_1	0.1389
p.R174H	SIDM01608	Endometrial Carcinoma	GDSC	DSGSDLS	DEG_SCF_TRCP1_1	0.1389
p.R174H	ACH-000990	Endometrial/Uterine Cancer	CCLE	DSGSDLS	DEG_SCF_TRCP1_1	0.1389
p.R174H	ACH-001127	Leukemia	CCLE	DSGSDLS	DEG_SCF_TRCP1_1	0.1389
p.R174H	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	DSGSDLS	DEG_SCF_TRCP1_1	0.1389
p.R172C	TCGA-B5-A3FC	UCEC	TCGA	DSGSDLS	DEG_SCF_TRCP1_1	0.1944
p.R172C	DO41871	UCEC	ICGC	DSGSDLS	DEG_SCF_TRCP1_1	0.1944
p.P170S	DO224967	BRCA	ICGC	DSGSDLS	DEG_SCF_TRCP1_1	0.25
p.P170S	DO227854	BRCA	ICGC	DSGSDLS	DEG_SCF_TRCP1_1	0.25
p.S158A	DO44798	LICA	ICGC	DSGSDLS	DEG_SCF_TRCP1_1	0.6944
p.M157T	SIDM01545	Non-Small Cell Lung Carcinoma	GDSC	DSGSDLS	DEG_SCF_TRCP1_1	0.2222
p.M157T	ACH-000511	Lung Cancer	CCLE	DSGSDLS	DEG_SCF_TRCP1_1	0.2222
p.A154D	SIDM01510	Non-Small Cell Lung Carcinoma	GDSC	DSGSDLS	DEG_SCF_TRCP1_1	0.1389
p.A154D	ACH-000925	Lung Cancer	CCLE	DSGSDLS	DEG_SCF_TRCP1_1	0.1389
p.R175C	RCC-AB	kidney	COSMIC	DSGSDLS	DEG_SCF_TRCP1_1	0.1111
p.R175Q	SK-MEL-2	skin	COSMIC	DSGSDLS	DEG_SCF_TRCP1_1	0.1111
p.R175W	HCT-15	large_intestine	COSMIC	DSGSDLS	DEG_SCF_TRCP1_1	0.1111
p.N166H	NCI-H322M	lung	COSMIC	DSGSDLS	DEG_SCF_TRCP1_1	0.7423
p.L158F	MZ7-mel	skin	COSMIC	DSGSDLS	DEG_SCF_TRCP1_1	0.6944
p.R158C	RCC-AB	kidney	COSMIC	DSGSDLS	DEG_SCF_TRCP1_1	0.6944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSGSDLS

Degron related mutations and impact score

Drug responses associated with KAT7 mutations

All proteins holding degron of DSGSDLS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95251	Histone acetyltransferase KAT7	DEG_SCF_TRCP1_1	161:167	DSGSDLS	BTRC	0.9674	More...