DegronMD

Uniprot ID: Q3KP66

Source protein: Innate immunity activator protein

Source gene: INAVA

Class: DEG_SCF_TRCP1_1

Location: 456:462

E3 ligase: BTRC

DEGRON score: 0.985

ASA_SCORE: 81.0857

COIL: 0.9276

CONS_SCORE: 0.636

DSS_SCORE: 0.5145

HELIX: 0.0393

FCONS_SCORE: 1.2837

RIG_SCORE: 0.5581

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P446L	SIDM02064	Colorectal Carcinoma	GDSC	DSGSDVS	DEG_SCF_TRCP1_1	0.0556
p.P459A	SIDM00267	Biliary Tract Carcinoma	GDSC	DSGSDVS	DEG_SCF_TRCP1_1	0.7503
p.P459A	SIDM00989	Bladder Carcinoma	GDSC	DSGSDVS	DEG_SCF_TRCP1_1	0.7503
p.A455S	SIDM00872	Breast Carcinoma	GDSC	DSGSDVS	DEG_SCF_TRCP1_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q3KP66	Innate immunity activator protein	DEG_SCF_TRCP1_1	456:462	DSGSDVS	BTRC	0.985	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons