DegronMD

Uniprot ID: Q99447

Source protein: Ethanolamine-phosphate cytidylyltransferase

Source gene: PCYT2

Class: DEG_SCF_TRCP1_1

Location: 335:341

E3 ligase: BTRC

DEGRON score: 0.9947

ASA_SCORE: 60.0857

COIL: 0.86

CONS_SCORE: 0.3468

DSS_SCORE: 0.2877

HELIX: 0.0189

FCONS_SCORE: 0.7555

RIG_SCORE: 0.7096

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K344N	TCGA-AX-A2HC	UCEC	TCGA	DSGSNLT	DEG_SCF_TRCP1_1	0.25
p.D333N	TCGA-IR-A3LA	CESC	TCGA	DSGSNLT	DEG_SCF_TRCP1_1	0.2778
p.D333G	SIDM01749	Osteosarcoma	GDSC	DSGSNLT	DEG_SCF_TRCP1_1	0.2778
p.R348Q	ACH-001415	Bladder Cancer	CCLE	DSGSNLT	DEG_SCF_TRCP1_1	0.1389
p.A342S	SNU-175	large_intestine	COSMIC	DSGSNLT	DEG_SCF_TRCP1_1	0.75

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q99447	Ethanolamine-phosphate cytidylyltransferase	DEG_SCF_TRCP1_1	335:341	DSGSNLT	BTRC	0.9947	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons