DegronMD

Uniprot ID: Q96EB6

Source protein: NAD-dependent protein deacetylase sirtuin-1

Source gene: SIRT1

Class: DEG_SCF_TRCP1_1

Location: 676:682

E3 ligase: BTRC

DEGRON score: 0.9909

ASA_SCORE: 88.2714

COIL: 0.9504

CONS_SCORE: 0.301

DSS_SCORE: 0.6964

HELIX: 0.026

FCONS_SCORE: 1.0454

RIG_SCORE: 0.5804

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S675N	TCGA-AZ-4315	COAD	TCGA	DSGTCQS	DEG_SCF_TRCP1_1	0.3056
p.Q681H	TCGA-E2-A1LG	BRCA	TCGA	DSGTCQS	DEG_SCF_TRCP1_1	0.647
p.E687K	SIDM00118	Colorectal Carcinoma	GDSC	DSGTCQS	DEG_SCF_TRCP1_1	0.1944
p.E687K	ACH-001081	Colon/Colorectal Cancer	CCLE	DSGTCQS	DEG_SCF_TRCP1_1	0.1944
p.E687K	HCC2998	large_intestine	COSMIC	DSGTCQS	DEG_SCF_TRCP1_1	0.1944
p.S673G	SIDM01608	Endometrial Carcinoma	GDSC	DSGTCQS	DEG_SCF_TRCP1_1	0.25
p.S673G	ACH-000990	Endometrial/Uterine Cancer	CCLE	DSGTCQS	DEG_SCF_TRCP1_1	0.25

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00841	COREAD\|large_intestine	p.V383I (No)	GDSC	Selisistat	234.3646
SIDM00951	LAML\|acute_myeloid_leukaemia	p.L478V (No)	GDSC	Selisistat	77.29
SIDM00782	COREAD\|large_intestine	p.D379N (No)	GDSC	Selisistat	339.5601
SIDM01007	ALL\|lymphoblastic_leukemia	p.I256fs*2 (No)	GDSC	Selisistat	87.1222
SIDM00145	ALL\|lymphoblastic_leukemia	p.F414fs*13 (No)	GDSC	Selisistat	125.1844
SIDM00619	THCA\|thyroid	p.G355V (No)	GDSC	Selisistat	79.5472
SIDM00770	SCLC\|lung_small_cell_carcinoma	p.G495D (No)	GDSC	Selisistat	367.6381
SIDM00304	OV\|ovary	p.S324fs*8 (No)	GDSC	Selisistat	447.8266
SIDM00602	STAD\|stomach	p.R237fs*11 (No)	GDSC	Selisistat	298.1516
SIDM00783	COREAD\|large_intestine	p.I256fs*2 (No)	GDSC	Selisistat	142.6314
SIDM00898	BRCA\|breast	p.T177I (No)	GDSC	Selisistat	287.6047
SIDM00685	GBM\|glioma	p.P393R (No)	GDSC	Selisistat	131.2062
SIDM00150	COREAD\|large_intestine	p.M407T (No)	GDSC	Selisistat	170.1144
SIDM00375	HNSC\|head_and_neck	p.A712T (No)	GDSC	Selisistat	325.9115
SIDM00789	COREAD\|large_intestine	p.R181W (No)	GDSC	Selisistat	198.5977
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.F414fs*13 (No)	GDSC	Selisistat	112.6936
SIDM00895	DLBC\|B_cell_lymphoma	p.S668F (Yes)	GDSC	Selisistat	124.056
SIDM01081	HNSC\|head_and_neck	p.I270K (No)	GDSC	Selisistat	292.294
SIDM00299	UNCLASSIFIED\|soft_tissue_other	p.A712T (No)	GDSC	Selisistat	332.9169
SIDM00447	UNCLASSIFIED\|B_cell_leukemia	p.R649H (No)	GDSC	Selisistat	156.663
SIDM00193	COREAD\|large_intestine	p.K238T (No)	GDSC	Selisistat	474.4698
SIDM00193	COREAD\|large_intestine	p.E725G (No)	GDSC	Selisistat	474.4698
SIDM00118	COREAD\|large_intestine	p.E520* (No)	GDSC	Selisistat	256.5652
SIDM00118	COREAD\|large_intestine	p.E687K (Yes)	GDSC	Selisistat	256.5652

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96EB6	NAD-dependent protein deacetylase sirtuin-1	DEG_SCF_TRCP1_1	676:682	DSGTCQS	BTRC	0.9909	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSGTCQS

Degron related mutations and impact score

Drug responses associated with SIRT1 mutations

All proteins holding degron of DSGTCQS