DegronMD

Uniprot ID: Q96DX4

Source protein: RING finger and SPRY domain-containing protein 1

Source gene: RSPRY1

Class: DEG_SCF_TRCP1_1

Location: 49:55

E3 ligase: BTRC

DEGRON score: 0.9772

ASA_SCORE: 80.3571

COIL: 0.908

CONS_SCORE: 0.3471

DSS_SCORE: 0.5318

HELIX: 0.0624

FCONS_SCORE: 0.9107

RIG_SCORE: 0.6765

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q60H	TCGA-AX-A06F	UCEC	TCGA	DSGTDDS	DEG_SCF_TRCP1_1	0.1944
p.Q60H	DO41752	UCEC	ICGC	DSGTDDS	DEG_SCF_TRCP1_1	0.1944
p.R47Q	TCGA-JX-A3Q0	CESC	TCGA	DSGTDDS	DEG_SCF_TRCP1_1	0.2778
p.R47Q	DO51607	CESC	ICGC	DSGTDDS	DEG_SCF_TRCP1_1	0.2778
p.R47Q	SIDM00390	T-Cell Non-Hodgkin's Lymphoma	GDSC	DSGTDDS	DEG_SCF_TRCP1_1	0.2778
p.G51E	TCGA-N8-A56S	UCS	TCGA	DSGTDDS	DEG_SCF_TRCP1_1	0.7199
p.G41C	DO228952	LICA	ICGC	DSGTDDS	DEG_SCF_TRCP1_1	0.1111
p.S55N	DO32904	PACA	ICGC	DSGTDDS	DEG_SCF_TRCP1_1	0.818

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96DX4	RING finger and SPRY domain-containing protein 1	DEG_SCF_TRCP1_1	49:55	DSGTDDS	BTRC	0.9772	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons