DegronMD

Uniprot ID: P49427

Source protein: Ubiquitin-conjugating enzyme E2 R1

Source gene: CDC34

Class: DEG_SCF_TRCP1_1

Location: 230:236

E3 ligase: BTRC

DEGRON score: 0.9839

ASA_SCORE: 102.3429

COIL: 0.9434

CONS_SCORE: 0.4943

DSS_SCORE: 0.9773

HELIX: 0.0417

FCONS_SCORE: 1.3141

RIG_SCORE: 0.6456

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A220V	TCGA-DD-AACI	LIHC	TCGA	DSGTEES	DEG_SCF_TRCP1_1	0.0556
p.A220V	DO52205	LIHC	ICGC	DSGTEES	DEG_SCF_TRCP1_1	0.0556
p.G232V	DO228952	LICA	ICGC	DSGTEES	DEG_SCF_TRCP1_1	0.7532
p.E235D	DO229028	LICA	ICGC	DSGTEES	DEG_SCF_TRCP1_1	0.5647
p.D227N	SIDM01048	Plasma Cell Myeloma	GDSC	DSGTEES	DEG_SCF_TRCP1_1	0.25
p.D227N	SIDM00951	T-Lymphoblastic Leukemia	GDSC	DSGTEES	DEG_SCF_TRCP1_1	0.25
p.D227N	ACH-000821	Myeloma	CCLE	DSGTEES	DEG_SCF_TRCP1_1	0.25
p.D227N	ACH-002222	Leukemia	CCLE	DSGTEES	DEG_SCF_TRCP1_1	0.25
p.D227N	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	DSGTEES	DEG_SCF_TRCP1_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P49427	Ubiquitin-conjugating enzyme E2 R1	DEG_SCF_TRCP1_1	230:236	DSGTEES	BTRC	0.9839	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons