DegronMD

Uniprot ID: Q8N3X6

Source protein: Ligand-dependent nuclear receptor corepressor-like protein

Source gene: LCORL

Class: DEG_SCF_TRCP1_1

Location: 589:594

E3 ligase: BTRC

DEGRON score: 0.9873

ASA_SCORE: 72.0833

COIL: 0.9032

CONS_SCORE: 0.4428

DSS_SCORE: 0.5733

HELIX: 0.0693

FCONS_SCORE: 1.0395

RIG_SCORE: 0.6337

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K596R	SIDM00845	Burkitt's Lymphoma	GDSC	DSGTGS	DEG_SCF_TRCP1_1	0.2778
p.K596R	SIDM00946	T-Lymphoblastic Leukemia	GDSC	DSGTGS	DEG_SCF_TRCP1_1	0.2778
p.G583E	SIDM01113	Other Sarcomas	GDSC	DSGTGS	DEG_SCF_TRCP1_1	0.1667
p.G583E	ACH-000939	Sarcoma	CCLE	DSGTGS	DEG_SCF_TRCP1_1	0.1667
p.G583E	SK-UT-1	soft_tissue	COSMIC	DSGTGS	DEG_SCF_TRCP1_1	0.1667
p.V602L	SIDM00488	Colorectal Carcinoma	GDSC	DSGTGS	DEG_SCF_TRCP1_1	0.1111
p.V602L	CaR-1	large_intestine	COSMIC	DSGTGS	DEG_SCF_TRCP1_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N3X6	Ligand-dependent nuclear receptor corepressor-like protein	DEG_SCF_TRCP1_1	589:594	DSGTGS	BTRC	0.9873	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons