DegronMD

Uniprot ID: Q9BYX4

Source protein: Interferon-induced helicase C domain-containing protein 1

Source gene: IFIH1

Class: DEG_SCF_TRCP1_1

Location: 283:289

E3 ligase: BTRC

DEGRON score: 0.9902

ASA_SCORE: 72.0429

COIL: 0.8477

CONS_SCORE: 0.4316

DSS_SCORE: 0.7438

HELIX: 0.0903

FCONS_SCORE: 1.0712

RIG_SCORE: 0.5245

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E293K	DO48446	BLCA	ICGC	DSGTMGS	DEG_SCF_TRCP1_1	0.2222
p.H276R	DO218673	GACA	ICGC	DSGTMGS	DEG_SCF_TRCP1_1	0.1389
p.N277K	DO229041	LICA	ICGC	DSGTMGS	DEG_SCF_TRCP1_1	0.1667
p.N277K	DO229008	LICA	ICGC	DSGTMGS	DEG_SCF_TRCP1_1	0.1667
p.S282R	SIDM00845	Burkitt's Lymphoma	GDSC	DSGTMGS	DEG_SCF_TRCP1_1	0.3056
p.S282R	SIDM00035	Thyroid Gland Carcinoma	GDSC	DSGTMGS	DEG_SCF_TRCP1_1	0.3056
p.S282R	SIDM00461	Acute Myeloid Leukemia	GDSC	DSGTMGS	DEG_SCF_TRCP1_1	0.3056
p.S282R	SIDM00946	T-Lymphoblastic Leukemia	GDSC	DSGTMGS	DEG_SCF_TRCP1_1	0.3056
p.S282R	SIDM01519	Head and Neck Carcinoma	GDSC	DSGTMGS	DEG_SCF_TRCP1_1	0.3056
p.S282R	ACH-000037	Sarcoma	CCLE	DSGTMGS	DEG_SCF_TRCP1_1	0.3056
p.S282R	ACH-000786	Lymphoma	CCLE	DSGTMGS	DEG_SCF_TRCP1_1	0.3056
p.S282R	ACH-000992	Head and Neck Cancer	CCLE	DSGTMGS	DEG_SCF_TRCP1_1	0.3056
p.S282R	ACH-001067	Brain Cancer	CCLE	DSGTMGS	DEG_SCF_TRCP1_1	0.3056
p.S282R	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	DSGTMGS	DEG_SCF_TRCP1_1	0.3056
p.S282R	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	DSGTMGS	DEG_SCF_TRCP1_1	0.3056
p.S282R	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	DSGTMGS	DEG_SCF_TRCP1_1	0.3056
p.S282R	S-117	soft_tissue	COSMIC	DSGTMGS	DEG_SCF_TRCP1_1	0.3056
p.H276Q	SIDM01259	B-Lymphoblastic Leukemia	GDSC	DSGTMGS	DEG_SCF_TRCP1_1	0.1389
p.H276Q	ACH-001669	Leukemia	CCLE	DSGTMGS	DEG_SCF_TRCP1_1	0.1389
p.H276Q	ACH-002238	Leukemia	CCLE	DSGTMGS	DEG_SCF_TRCP1_1	0.1389
p.H276Q	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	DSGTMGS	DEG_SCF_TRCP1_1	0.1389
p.S273R	SIDM01611	Endometrial Carcinoma	GDSC	DSGTMGS	DEG_SCF_TRCP1_1	0.0556
p.S273R	ACH-000996	Endometrial/Uterine Cancer	CCLE	DSGTMGS	DEG_SCF_TRCP1_1	0.0556
p.A298G	ACH-000202	Colon/Colorectal Cancer	CCLE	DSGTMGS	DEG_SCF_TRCP1_1	0.0833
p.A298G	ACH-000997	Colon/Colorectal Cancer	CCLE	DSGTMGS	DEG_SCF_TRCP1_1	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSGTMGS

Degron related mutations and impact score

Drug responses associated with IFIH1 mutations

All proteins holding degron of DSGTMGS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BYX4	Interferon-induced helicase C domain-containing protein 1	DEG_SCF_TRCP1_1	283:289	DSGTMGS	BTRC	0.9902	More...