DegronMD

Uniprot ID: Q00987

Source protein: E3 ubiquitin-protein ligase Mdm2

Source gene: MDM2

Class: DEG_SCF_TRCP1_1

Location: 117:123

E3 ligase: BTRC

DEGRON score: 0.9807

ASA_SCORE: 76.7571

COIL: 0.8507

CONS_SCORE: 0.3755

DSS_SCORE: 0.5796

HELIX: 0.1009

FCONS_SCORE: 1.0203

RIG_SCORE: 0.6227

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S127F	TCGA-06-5416	GBM	TCGA	DSGTSVS	DEG_SCF_TRCP1_1	0.2222
p.H126Y	DO48386	BLCA	ICGC	DSGTSVS	DEG_SCF_TRCP1_1	0.25
p.R130T	DO222692	ESCA	ICGC	DSGTSVS	DEG_SCF_TRCP1_1	0.1389
p.R130I	DO229037	LICA	ICGC	DSGTSVS	DEG_SCF_TRCP1_1	0.1389
p.P122H	DO25360	LUAD	ICGC	DSGTSVS	DEG_SCF_TRCP1_1	0.7694
p.Q115P	DO27208	LUSC	ICGC	DSGTSVS	DEG_SCF_TRCP1_1	0.2778
p.E120D	DO42793	UCEC	ICGC	DSGTSVS	DEG_SCF_TRCP1_1	0.6758
p.H128D	DSH1	urinary_tract	COSMIC	DSGTSVS	DEG_SCF_TRCP1_1	0.1944
p.L120F	RVH-421	skin	COSMIC	DSGTSVS	DEG_SCF_TRCP1_1	0.6981
p.L120F	COLO-741	large_intestine	COSMIC	DSGTSVS	DEG_SCF_TRCP1_1	0.6981
p.L126V	AGS	stomach	COSMIC	DSGTSVS	DEG_SCF_TRCP1_1	0.25
p.D132V	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	DSGTSVS	DEG_SCF_TRCP1_1	0.0833
p.S128P	REH	haematopoietic_and_lymphoid_tissue	COSMIC	DSGTSVS	DEG_SCF_TRCP1_1	0.1944
p.K108N	HT-115	large_intestine	COSMIC	DSGTSVS	DEG_SCF_TRCP1_1	0.0833
p.C113Y	CW-2	large_intestine	COSMIC	DSGTSVS	DEG_SCF_TRCP1_1	0.2222
p.D107V	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	DSGTSVS	DEG_SCF_TRCP1_1	0.0556
p.I131S	SNU-81	large_intestine	COSMIC	DSGTSVS	DEG_SCF_TRCP1_1	0.1111
p.E132D	SJSA-1	bone	COSMIC	DSGTSVS	DEG_SCF_TRCP1_1	0.0833

Drug responses associated with MDM2 mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
ACH-000311	Lung Cancer	p.S4R (No)	CCLE	Nutlin-3	4.5991
ACH-000111	Breast Cancer	p.LKL35fs (No)	CCLE	Nutlin-3	8
ACH-000649	Kidney Cancer	p.I164T (No)	CCLE	Nutlin-3	8
ACH-000483	Liver Cancer	p.D214H (No)	CCLE	Nutlin-3	8
ACH-000996	Endometrial/Uterine Cancer	p.P270T (No)	CCLE	Nutlin-3	8
ACH-000960	Leukemia	p.S273P (No)	CCLE	Nutlin-3	7.5875
ACH-000985	Colon/Colorectal Cancer	p.P289fs (No)	CCLE	Nutlin-3	8
ACH-000748	Bone Cancer	p.E302D (No)	CCLE	Nutlin-3	6.4565
ACH-000930	Breast Cancer	p.EDKG307del (No)	CCLE	Nutlin-3	8
ACH-000879	Endometrial/Uterine Cancer	p.K339fs (No)	CCLE	Nutlin-3	8
ACH-000936	Ovarian Cancer	p.K339fs (No)	CCLE	Nutlin-3	8
ACH-000410	Bone Cancer	p.S400N (No)	CCLE	Nutlin-3	8
SIDM00217	COREAD\|large_intestine	p.T371fs*2 (No)	GDSC	Nutlin-3a (-)	134.77
SIDM00970	BLCA\|bladder	p.H134D (Yes)	GDSC	Nutlin-3a (-)	61.8194
SIDM00970	BLCA\|bladder	p.H134D (Yes)	GDSC	Serdemetan	2.543
SIDM00970	BLCA\|bladder	p.H134D (Yes)	GDSC	Nutlin-3a (-)	438.69
SIDM00433	ALL\|lymphoblastic_T_cell_leukaemia	p.E210G (No)	GDSC	Nutlin-3a (-)	15.9098
SIDM00433	ALL\|lymphoblastic_T_cell_leukaemia	p.E210G (No)	GDSC	Serdemetan	15.7649
SIDM00433	ALL\|lymphoblastic_T_cell_leukaemia	p.E210G (No)	GDSC	Nutlin-3a (-)	21.911
SIDM01051	UNCLASSIFIED\|ovary	p.T371fs*2 (No)	GDSC	Nutlin-3a (-)	60.3457
SIDM01051	UNCLASSIFIED\|ovary	p.T371fs*2 (No)	GDSC	Serdemetan	20.4884
SIDM00145	ALL\|lymphoblastic_leukemia	p.D386V (No)	GDSC	Nutlin-3a (-)	3.315
SIDM00145	ALL\|lymphoblastic_leukemia	p.D386V (No)	GDSC	Serdemetan	13.9015
SIDM00145	ALL\|lymphoblastic_leukemia	p.D386V (No)	GDSC	Nutlin-3a (-)	1.0069
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.L321fs*52 (No)	GDSC	Nutlin-3a (-)	27.9503
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.L321fs*52 (No)	GDSC	Serdemetan	7.1021
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.L321fs*52 (No)	GDSC	Nutlin-3a (-)	60.558
SIDM00334	UCEC\|endometrium	p.T371fs*2 (No)	GDSC	Nutlin-3a (-)	7.793
SIDM00334	UCEC\|endometrium	p.T371fs*2 (No)	GDSC	Serdemetan	43.6713
SIDM00334	UCEC\|endometrium	p.T371fs*2 (No)	GDSC	Nutlin-3a (-)	166.02
SIDM00498	COREAD\|large_intestine	p.D52N (No)	GDSC	Nutlin-3a (-)	150.1991
SIDM00498	COREAD\|large_intestine	p.D52N (No)	GDSC	Serdemetan	65.4414
SIDM00498	COREAD\|large_intestine	p.D52N (No)	GDSC	Nutlin-3a (-)	285.14
SIDM00441	LAML\|acute_myeloid_leukaemia	p.M465I (No)	GDSC	Nutlin-3a (-)	4.7486
SIDM00441	LAML\|acute_myeloid_leukaemia	p.M465I (No)	GDSC	Serdemetan	26.9908
SIDM00441	LAML\|acute_myeloid_leukaemia	p.M465I (No)	GDSC	Nutlin-3a (-)	1.5592
SIDM00401	SKCM\|melanoma	p.L321F (No)	GDSC	Nutlin-3a (-)	5.7153
SIDM00401	SKCM\|melanoma	p.L321F (No)	GDSC	Serdemetan	12.4277
SIDM00217	COREAD\|large_intestine	p.R189H (No)	GDSC	Nutlin-3a (-)	134.77
SIDM00282	COREAD\|large_intestine	p.C314Y (No)	GDSC	Nutlin-3a (-)	23.3784
SIDM00282	COREAD\|large_intestine	p.C314Y (No)	GDSC	Serdemetan	9.7449
SIDM00282	COREAD\|large_intestine	p.C314Y (No)	GDSC	Nutlin-3a (-)	11.135
SIDM01084	UNCLASSIFIED\|osteosarcoma	p.S431N (No)	GDSC	Nutlin-3a (-)	218.8928
SIDM01084	UNCLASSIFIED\|osteosarcoma	p.S431N (No)	GDSC	Serdemetan	27.6877
SIDM01084	UNCLASSIFIED\|osteosarcoma	p.S431N (No)	GDSC	Nutlin-3a (-)	135.03
SIDM00660	COREAD\|large_intestine	p.L321fs*52 (No)	GDSC	Nutlin-3a (-)	147.514
SIDM00660	COREAD\|large_intestine	p.L321fs*52 (No)	GDSC	Serdemetan	20.4574
SIDM00660	COREAD\|large_intestine	p.L321fs*52 (No)	GDSC	Nutlin-3a (-)	668.75
SIDM00878	BRCA\|breast	p.E338_G341delEDKG (No)	GDSC	Nutlin-3a (-)	33.7689
SIDM00878	BRCA\|breast	p.E338_G341delEDKG (No)	GDSC	Serdemetan	11.453
SIDM00878	BRCA\|breast	p.E338_G341delEDKG (No)	GDSC	Nutlin-3a (-)	65.786
SIDM00534	COREAD\|large_intestine	p.K475N (No)	GDSC	Nutlin-3a (-)	113.1934
SIDM00534	COREAD\|large_intestine	p.K475N (No)	GDSC	Serdemetan	25.4428
SIDM00534	COREAD\|large_intestine	p.K475N (No)	GDSC	Nutlin-3a (-)	244.24
SIDM00850	STAD\|stomach	p.L181V (No)	GDSC	Nutlin-3a (-)	3.7204
SIDM00850	STAD\|stomach	p.L181V (No)	GDSC	Serdemetan	4.3442
SIDM00850	STAD\|stomach	p.L181V (No)	GDSC	Nutlin-3a (-)	5.4494
SIDM01112	UNCLASSIFIED\|bone_other	p.E333D (No)	GDSC	Nutlin-3a (-)	3.5402
SIDM01112	UNCLASSIFIED\|bone_other	p.E333D (No)	GDSC	Serdemetan	33.6166
SIDM01112	UNCLASSIFIED\|bone_other	p.E333D (No)	GDSC	Nutlin-3a (-)	1.9651
SIDM01151	LIHC\|liver	p.D245H (No)	GDSC	Nutlin-3a (-)	92.4765
SIDM01151	LIHC\|liver	p.D245H (No)	GDSC	Serdemetan	11.5461
SIDM01151	LIHC\|liver	p.D245H (No)	GDSC	Nutlin-3a (-)	513.29
SIDM00364	ALL\|lymphoblastic_leukemia	p.T371fs*5 (No)	GDSC	Nutlin-3a (-)	5.9454
SIDM00364	ALL\|lymphoblastic_leukemia	p.T371fs*5 (No)	GDSC	Serdemetan	13.2539
SIDM00364	ALL\|lymphoblastic_leukemia	p.T371fs*5 (No)	GDSC	Nutlin-3a (-)	5.5112
SIDM00878	BRCA\|breast	p.E338K (No)	GDSC	Nutlin-3a (-)	33.7689
SIDM00878	BRCA\|breast	p.E338K (No)	GDSC	Serdemetan	11.453
SIDM00878	BRCA\|breast	p.E338K (No)	GDSC	Nutlin-3a (-)	65.786
SIDM00447	UNCLASSIFIED\|B_cell_leukemia	p.S304P (No)	GDSC	Nutlin-3a (-)	5.889
SIDM00447	UNCLASSIFIED\|B_cell_leukemia	p.S304P (No)	GDSC	Serdemetan	11.0541
SIDM00447	UNCLASSIFIED\|B_cell_leukemia	p.S304P (No)	GDSC	Nutlin-3a (-)	5.6354
SIDM00193	COREAD\|large_intestine	p.I410S (No)	GDSC	Nutlin-3a (-)	92.47
SIDM00193	COREAD\|large_intestine	p.I410S (No)	GDSC	Serdemetan	38.2609
SIDM00193	COREAD\|large_intestine	p.I410S (No)	GDSC	Nutlin-3a (-)	197.53

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSGTSVS

Degron related mutations and impact score

Drug responses associated with MDM2 mutations

All proteins holding degron of DSGTSVS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q00987	E3 ubiquitin-protein ligase Mdm2	DEG_SCF_TRCP1_1	117:123	DSGTSVS	BTRC	0.9807	More...