DegronMD

Uniprot ID: Q9NPB8

Source protein: Glycerophosphocholine phosphodiesterase GPCPD1

Source gene: GPCPD1

Class: DEG_SCF_TRCP1_1

Location: 123:128

E3 ligase: BTRC

DEGRON score: 0.6931

ASA_SCORE: 51.3833

COIL: 0.5262

CONS_SCORE: 0.398

DSS_SCORE: 0.1984

HELIX: 0.0435

FCONS_SCORE: 1.2712

RIG_SCORE: 0.84

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F113L	TCGA-56-8622	LUSC	TCGA	DSGWLT	DEG_SCF_TRCP1_1	0.0556
p.F113L	DO45449	LUSC	ICGC	DSGWLT	DEG_SCF_TRCP1_1	0.0556
p.F113S	TCGA-DX-AB32	SARC	TCGA	DSGWLT	DEG_SCF_TRCP1_1	0.0556
p.F113S	DO220102	SARC	ICGC	DSGWLT	DEG_SCF_TRCP1_1	0.0556
p.C129Y	TCGA-XF-A9T5	BLCA	TCGA	DSGWLT	DEG_SCF_TRCP1_1	0.3056
p.C129Y	DO51925	BLCA	ICGC	DSGWLT	DEG_SCF_TRCP1_1	0.3056
p.R136H	DO222501	COCA	ICGC	DSGWLT	DEG_SCF_TRCP1_1	0.1111
p.T121P	DO222762	COCA	ICGC	DSGWLT	DEG_SCF_TRCP1_1	0.2778
p.D123E	DO50319	ESAD	ICGC	DSGWLT	DEG_SCF_TRCP1_1	0.6758

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NPB8	Glycerophosphocholine phosphodiesterase GPCPD1	DEG_SCF_TRCP1_1	123:128	DSGWLT	BTRC	0.6931	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons