DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
DSTEYSQPP
Uniprot ID:
Q8NHY2
Source protein:
E3 ubiquitin-protein ligase COP1
Source gene:
COP1
Class:
CBL_PTK
Location:
327:335
E3 ligase:
CBL
DEGRON score:
0.9422
ASA_SCORE:
76.3667
COIL:
0.8234
CONS_SCORE:
0.3235
DSS_SCORE:
0.642
HELIX:
0.1162
FCONS_SCORE:
0.9678
RIG_SCORE:
0.6375
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.S324G
SIDM01045
Endometrial Carcinoma
GDSC
DSTEYSQPP
CBL_PTK
0.25
p.S324G
EN
endometrium
COSMIC
DSTEYSQPP
CBL_PTK
0.25
p.Q342L
SIDM00758
Non-Small Cell Lung Carcinoma
GDSC
DSTEYSQPP
CBL_PTK
0.1389
p.Q342L
SIDM00757
Non-Small Cell Lung Carcinoma
GDSC
DSTEYSQPP
CBL_PTK
0.1389
p.Q342L
NCI-H1993
lung
COSMIC
DSTEYSQPP
CBL_PTK
0.1389
p.R335Q
SNG-M
endometrium
COSMIC
DSTEYSQPP
CBL_PTK
0.7329
p.R335Q
SNU-81
large_intestine
COSMIC
DSTEYSQPP
CBL_PTK
0.7329
p.Q318L
NCI-H1993
lung
COSMIC
DSTEYSQPP
CBL_PTK
0.0833
Drug responses associated with COP1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DSTEYSQPP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8NHY2
E3 ubiquitin-protein ligase COP1
CBL_PTK
327:335
DSTEYSQPP
CBL
0.9422
More...
