DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
DSYSPIP
Uniprot ID:
Q8WUY3
Source protein:
Protein prune homolog 2
Source gene:
PRUNE2
Class:
CBL_PTK
Location:
467:473
E3 ligase:
CBL
DEGRON score:
0.9457
ASA_SCORE:
51.7
COIL:
0.9187
CONS_SCORE:
0.6137
DSS_SCORE:
0.5206
HELIX:
0.0261
FCONS_SCORE:
1.1251
RIG_SCORE:
0.6826
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.A476V
TCGA-BR-4184
STAD
TCGA
DSYSPIP
CBL_PTK
0.25
p.L466F
TCGA-D3-A3ML
SKCM
TCGA
DSYSPIP
CBL_PTK
0.3056
p.E480K
TCGA-GN-A266
SKCM
TCGA
DSYSPIP
CBL_PTK
0.1389
p.P473S
TCGA-GN-A8LK
SKCM
TCGA
DSYSPIP
CBL_PTK
0.6752
p.A478V
TCGA-VQ-A91V
STAD
TCGA
DSYSPIP
CBL_PTK
0.1944
p.N458D
DO228483
BRCA
ICGC
DSYSPIP
CBL_PTK
0.0833
p.N458D
DO229016
COCA
ICGC
DSYSPIP
CBL_PTK
0.0833
p.N458D
DO229003
COCA
ICGC
DSYSPIP
CBL_PTK
0.0833
p.N458D
DO229353
LAML
ICGC
DSYSPIP
CBL_PTK
0.0833
p.N458D
DO230524
LUSC
ICGC
DSYSPIP
CBL_PTK
0.0833
p.N458D
DO230993
LUSC
ICGC
DSYSPIP
CBL_PTK
0.0833
p.N458D
DO230990
LUSC
ICGC
DSYSPIP
CBL_PTK
0.0833
p.N458D
DO231049
LUSC
ICGC
DSYSPIP
CBL_PTK
0.0833
p.D471V
DO1251
BRCA
ICGC
DSYSPIP
CBL_PTK
0.7785
p.G481V
DO3524
BRCA
ICGC
DSYSPIP
CBL_PTK
0.1111
p.P472Q
DO14766
HNSC
ICGC
DSYSPIP
CBL_PTK
0.7035
p.P472Q
DO229027
LICA
ICGC
DSYSPIP
CBL_PTK
0.7035
p.S468F
DO220891
MELA
ICGC
DSYSPIP
CBL_PTK
0.6871
p.P461Q
DO37901
SKCM
ICGC
DSYSPIP
CBL_PTK
0.1667
p.A478T
DO41020
UCEC
ICGC
DSYSPIP
CBL_PTK
0.1944
p.P472L
DO41235
UCEC
ICGC
DSYSPIP
CBL_PTK
0.7582
p.M477I
DO41235
UCEC
ICGC
DSYSPIP
CBL_PTK
0.2222
p.T462A
DO42440
UCEC
ICGC
DSYSPIP
CBL_PTK
0.1944
p.L459S
NCI-H441
lung
COSMIC
DSYSPIP
CBL_PTK
0.1111
p.L459V
BxPC-3
pancreas
COSMIC
DSYSPIP
CBL_PTK
0.1111
Drug responses associated with PRUNE2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DSYSPIP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8WUY3
Protein prune homolog 2
CBL_PTK
467:473
DSYSPIP
CBL
0.9457
More...