DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
DSYSRCP
Uniprot ID:
O14524
Source protein:
Nuclear envelope integral membrane protein 1
Source gene:
NEMP1
Class:
CBL_PTK
Location:
429:435
E3 ligase:
CBL
DEGRON score:
0.9881
ASA_SCORE:
91.5714
COIL:
0.8319
CONS_SCORE:
0.291
DSS_SCORE:
0.5477
HELIX:
0.1446
FCONS_SCORE:
0.8154
RIG_SCORE:
0.7532
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P435S
SIDM00478
Esophageal Squamous Cell Carcinoma
GDSC
DSYSRCP
CBL_PTK
0.6752
p.P435S
SIDM00100
Mesothelioma
GDSC
DSYSRCP
CBL_PTK
0.6752
Drug responses associated with NEMP1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DSYSRCP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O14524
Nuclear envelope integral membrane protein 1
CBL_PTK
429:435
DSYSRCP
CBL
0.9881
More...
