DegronMD

Uniprot ID: Q13501

Source protein: Sequestosome-1

Source gene: SQSTM1

Class: CBL_PTK

Location: 429:437

E3 ligase: CBL

DEGRON score: 0.8649

ASA_SCORE: 85.7667

COIL: 0.6151

CONS_SCORE: 0.5002

DSS_SCORE: 0.5337

HELIX: 0.3683

FCONS_SCORE: 0.821

RIG_SCORE: 0.7592

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A426V	TCGA-AF-2687	READ	TCGA	DTIQYSKHP	CBL_PTK	0.25
p.K420N	TCGA-AN-A046	BRCA	TCGA	DTIQYSKHP	CBL_PTK	0.5278
p.G425R	TCGA-DA-A3F5	SKCM	TCGA	DTIQYSKHP	CBL_PTK	0.2222
p.N421S	TCGA-HJ-7597	STAD	TCGA	DTIQYSKHP	CBL_PTK	0.1111
p.P438L	TCGA-QS-A5YR	UCEC	TCGA	DTIQYSKHP	CBL_PTK	0.3056
p.P438L	SIDM01062	Breast Carcinoma	GDSC	DTIQYSKHP	CBL_PTK	0.3056
p.P438L	ACH-000643	Breast Cancer	CCLE	DTIQYSKHP	CBL_PTK	0.3056
p.P438L	HDQ-P1	breast	COSMIC	DTIQYSKHP	CBL_PTK	0.3056
p.P439L	SIDM00521	Small Cell Lung Carcinoma	GDSC	DTIQYSKHP	CBL_PTK	0.2778
p.P439L	SIDM00457	Plasma Cell Myeloma	GDSC	DTIQYSKHP	CBL_PTK	0.2778
p.P439L	SIDM00294	Small Cell Lung Carcinoma	GDSC	DTIQYSKHP	CBL_PTK	0.2778
p.P439L	COR-L95	lung	COSMIC	DTIQYSKHP	CBL_PTK	0.2778
p.P439L	OPM-2	haematopoietic_and_lymphoid_tissue	COSMIC	DTIQYSKHP	CBL_PTK	0.2778
p.P439L	LU-135	lung	COSMIC	DTIQYSKHP	CBL_PTK	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13501	Sequestosome-1	CBL_PTK	429:437	DTIQYSKHP	CBL	0.8649	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons