DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
DTNYSTEP
Uniprot ID:
Q16659
Source protein:
Mitogen-activated protein kinase 6
Source gene:
MAPK6
Class:
CBL_PTK
Location:
416:423
E3 ligase:
CBL
DEGRON score:
0.7189
ASA_SCORE:
95.8875
COIL:
0.9015
CONS_SCORE:
0.3921
DSS_SCORE:
0.287
HELIX:
0.0621
FCONS_SCORE:
0.8826
RIG_SCORE:
0.7592
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.K408R
TCGA-DA-A1I5
SKCM
TCGA
DTNYSTEP
CBL_PTK
0.5556
p.K408R
DO37447
SKCM
ICGC
DTNYSTEP
CBL_PTK
0.5556
p.D429V
TCGA-DX-A1KW
SARC
TCGA
DTNYSTEP
CBL_PTK
0.1667
p.D429V
DO219945
SARC
ICGC
DTNYSTEP
CBL_PTK
0.1667
Drug responses associated with MAPK6 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DTNYSTEP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q16659
Mitogen-activated protein kinase 6
CBL_PTK
416:423
DTNYSTEP
CBL
0.7189
More...
