DegronMD

Uniprot ID: P48436

Source protein: Transcription factor SOX-9

Source gene: SOX9

Class: DEG_COP1_1

Location: 482:489

E3 ligase: COP1

DEGRON score: 0.9915

ASA_SCORE: 72.5375

COIL: 0.9101

CONS_SCORE: 0.3549

DSS_SCORE: 0.5871

HELIX: 0.0195

FCONS_SCORE: 0.9968

RIG_SCORE: 0.6482

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A481G	TCGA-35-4123	LUAD	TCGA	DTSGVPSI	DEG_COP1_1	0.3056
p.A481G	DO26394	LUAD	ICGC	DTSGVPSI	DEG_COP1_1	0.3056
p.R474C	TCGA-B5-A11Y	UCEC	TCGA	DTSGVPSI	DEG_COP1_1	0.1111
p.R474C	DO40889	UCEC	ICGC	DTSGVPSI	DEG_COP1_1	0.1111
p.P490L	TCGA-B5-A3FC	UCEC	TCGA	DTSGVPSI	DEG_COP1_1	0.3056
p.P490L	DO41871	UCEC	ICGC	DTSGVPSI	DEG_COP1_1	0.3056
p.R474H	TCGA-BR-8363	STAD	TCGA	DTSGVPSI	DEG_COP1_1	0.1111
p.R474H	DO47837	STAD	ICGC	DTSGVPSI	DEG_COP1_1	0.1111
p.S484A	TCGA-D1-A17Q	UCEC	TCGA	DTSGVPSI	DEG_COP1_1	0.6477
p.S484A	DO41903	UCEC	ICGC	DTSGVPSI	DEG_COP1_1	0.6477
p.S484F	TCGA-D3-A2JP	SKCM	TCGA	DTSGVPSI	DEG_COP1_1	0.6871
p.S484F	DO47407	SKCM	ICGC	DTSGVPSI	DEG_COP1_1	0.6871
p.G485V	TCGA-EE-A184	SKCM	TCGA	DTSGVPSI	DEG_COP1_1	0.6421
p.G485V	DO47442	SKCM	ICGC	DTSGVPSI	DEG_COP1_1	0.6421
p.S494N	TCGA-FW-A3R5	SKCM	TCGA	DTSGVPSI	DEG_COP1_1	0.1944
p.S494N	DO37406	SKCM	ICGC	DTSGVPSI	DEG_COP1_1	0.1944
p.Q473R	TCGA-HU-A4H3	STAD	TCGA	DTSGVPSI	DEG_COP1_1	0.0833
p.Q473R	DO47903	STAD	ICGC	DTSGVPSI	DEG_COP1_1	0.0833
p.H497N	TCGA-MT-A67A	HNSC	TCGA	DTSGVPSI	DEG_COP1_1	0.1111
p.H497N	DO49048	HNSC	ICGC	DTSGVPSI	DEG_COP1_1	0.1111
p.P479H	DO32912	PACA	ICGC	DTSGVPSI	DEG_COP1_1	0.25
p.Q496H	ACH-000954	Endometrial/Uterine Cancer	CCLE	DTSGVPSI	DEG_COP1_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P48436	Transcription factor SOX-9	DEG_COP1_1	482:489	DTSGVPSI	COP1	0.9915	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons