DegronMD

Uniprot ID: Q9UBR4

Source protein: LIM/homeobox protein Lhx3

Source gene: LHX3

Class: DEG_COP1_1

Location: 341:351

E3 ligase: COP1

DEGRON score: 0.8483

ASA_SCORE: 64.8636

COIL: 0.8851

CONS_SCORE: 0.4578

DSS_SCORE: 0.5429

HELIX: 0.0641

FCONS_SCORE: 0.9993

RIG_SCORE: 0.6411

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L344S	DO228246	BRCA	ICGC	DTSLGLVPSGA	DEG_COP1_1	0.6556
p.L344S	ACH-000633	Gastric Cancer	CCLE	DTSLGLVPSGA	DEG_COP1_1	0.6556
p.D341Y	DO222884	COCA	ICGC	DTSLGLVPSGA	DEG_COP1_1	0.7325
p.P357L	DO222875	MELA	ICGC	DTSLGLVPSGA	DEG_COP1_1	0.1667
p.P356L	DO229257	THCA	ICGC	DTSLGLVPSGA	DEG_COP1_1	0.1944
p.Q331H	DO229229	THCA	ICGC	DTSLGLVPSGA	DEG_COP1_1	0.0556
p.G358S	ACH-001518	Endometrial/Uterine Cancer	CCLE	DTSLGLVPSGA	DEG_COP1_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UBR4	LIM/homeobox protein Lhx3	DEG_COP1_1	341:351	DTSLGLVPSGA	COP1	0.8483	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons