DegronMD

Uniprot ID: P08865

Source protein: 40S ribosomal protein SA

Source gene: RPSA

Class: DEG_COP1_1

Location: 247:257

E3 ligase: COP1

DEGRON score: 0.999

ASA_SCORE: 68.7909

COIL: 0.8065

CONS_SCORE: 0.2583

DSS_SCORE: 0.568

HELIX: 0.0871

FCONS_SCORE: 1.0682

RIG_SCORE: 0.7553

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q253H	TCGA-5M-AAT6	COAD	TCGA	DWSEGVQVPSV	DEG_COP1_1	0.647
p.Q253H	TCGA-A5-A0G1	UCEC	TCGA	DWSEGVQVPSV	DEG_COP1_1	0.647
p.Q253H	DO223703	COAD	ICGC	DWSEGVQVPSV	DEG_COP1_1	0.647
p.Q253H	DO42472	UCEC	ICGC	DWSEGVQVPSV	DEG_COP1_1	0.647
p.Q261R	TCGA-AA-3984	COAD	TCGA	DWSEGVQVPSV	DEG_COP1_1	0.2222
p.Q261R	DO9002	COAD	ICGC	DWSEGVQVPSV	DEG_COP1_1	0.2222
p.P243S	TCGA-DK-A6AW	BLCA	TCGA	DWSEGVQVPSV	DEG_COP1_1	0.2222
p.P243S	DO48566	BLCA	ICGC	DWSEGVQVPSV	DEG_COP1_1	0.2222
p.S256F	TCGA-ZF-AA51	BLCA	TCGA	DWSEGVQVPSV	DEG_COP1_1	0.7982
p.S256F	DO219093	BLCA	ICGC	DWSEGVQVPSV	DEG_COP1_1	0.7982
p.A240D	DO223443	CLLE	ICGC	DWSEGVQVPSV	DEG_COP1_1	0.1389
p.P243L	DO234372	ESAD	ICGC	DWSEGVQVPSV	DEG_COP1_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P08865	40S ribosomal protein SA	DEG_COP1_1	247:257	DWSEGVQVPSV	COP1	0.999	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons