DegronMD

Uniprot ID: P20290

Source protein: Transcription factor BTF3

Source gene: BTF3

Class: DEG_COP1_1

Location: 184:193

E3 ligase: COP1

DEGRON score: 0.9994

ASA_SCORE: 83.9

COIL: 0.81

CONS_SCORE: 0.7042

DSS_SCORE: 0.7075

HELIX: 0.1494

FCONS_SCORE: 1.1822

RIG_SCORE: 0.7238

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A178S	TCGA-06-5416	GBM	TCGA	EDDDDEVPDL	DEG_COP1_1	0.1667
p.A181P	TCGA-55-A490	LUAD	TCGA	EDDDDEVPDL	DEG_COP1_1	0.25
p.E199D	TCGA-AA-3979	COAD	TCGA	EDDDDEVPDL	DEG_COP1_1	0.1667
p.D186G	TCGA-D1-A103	UCEC	TCGA	EDDDDEVPDL	DEG_COP1_1	0.6087
p.P191L	TCGA-D3-A5GO	SKCM	TCGA	EDDDDEVPDL	DEG_COP1_1	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P20290	Transcription factor BTF3	DEG_COP1_1	184:193	EDDDDEVPDL	COP1	0.9994	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons