DegronMD

Uniprot ID: Q5TCS8

Source protein: Adenylate kinase 9

Source gene: AK9

Class: DEG_COP1_1

Location: 819:828

E3 ligase: COP1

DEGRON score: 0.9948

ASA_SCORE: 75.49

COIL: 0.6798

CONS_SCORE: 0.4353

DSS_SCORE: 0.4891

HELIX: 0.2982

FCONS_SCORE: 1.1485

RIG_SCORE: 0.7573

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P815S	DO229003	COCA	ICGC	EDSYPDVPEM	DEG_COP1_1	0.2222
p.P815S	DO229346	LAML	ICGC	EDSYPDVPEM	DEG_COP1_1	0.2222
p.I835V	DO218068	GACA	ICGC	EDSYPDVPEM	DEG_COP1_1	0.1389
p.Y822H	ACH-000666	Lung Cancer	CCLE	EDSYPDVPEM	DEG_COP1_1	0.6118

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5TCS8	Adenylate kinase 9	DEG_COP1_1	819:828	EDSYPDVPEM	COP1	0.9948	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons