DegronMD

Uniprot ID: Q96DZ5

Source protein: CAP-Gly domain-containing linker protein 3

Source gene: CLIP3

Class: DEG_COP1_1

Location: 18:30

E3 ligase: COP1

DEGRON score: 0.8055

ASA_SCORE: 107.9154

COIL: 0.8131

CONS_SCORE: 0.4085

DSS_SCORE: 0.9194

HELIX: 0.1552

FCONS_SCORE: 1.0256

RIG_SCORE: 0.5592

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q35K	TCGA-99-8025	LUAD	TCGA	EEEEEEDEPVPEA	DEG_COP1_1	0.1944
p.Q35K	DO24255	LUAD	ICGC	EEEEEEDEPVPEA	DEG_COP1_1	0.1944
p.E21D	TCGA-F4-6570	COAD	TCGA	EEEEEEDEPVPEA	DEG_COP1_1	0.5647
p.E21D	DO10443	COAD	ICGC	EEEEEEDEPVPEA	DEG_COP1_1	0.5647
p.P12T	TCGA-ZJ-AB0I	CESC	TCGA	EEEEEEDEPVPEA	DEG_COP1_1	0.1667
p.P12T	DO219761	CESC	ICGC	EEEEEEDEPVPEA	DEG_COP1_1	0.1667
p.P11L	DO228941	LICA	ICGC	EEEEEEDEPVPEA	DEG_COP1_1	0.1389
p.P11L	SIDM01007	T-Lymphoblastic Leukemia	GDSC	EEEEEEDEPVPEA	DEG_COP1_1	0.1389
p.P11L	SIDM01781	Gastric Carcinoma	GDSC	EEEEEEDEPVPEA	DEG_COP1_1	0.1389
p.P11Q	DO228978	LICA	ICGC	EEEEEEDEPVPEA	DEG_COP1_1	0.1389
p.E29D	DO38404	STAD	ICGC	EEEEEEDEPVPEA	DEG_COP1_1	0.5647
p.R14G	ACH-000191	Thyroid Cancer	CCLE	EEEEEEDEPVPEA	DEG_COP1_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96DZ5	CAP-Gly domain-containing linker protein 3	DEG_COP1_1	18:30	EEEEEEDEPVPEA	COP1	0.8055	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons