DegronMD

Uniprot ID: Q6ZN55

Source protein: Zinc finger protein 574

Source gene: ZNF574

Class: DEG_COP1_1

Location: 187:198

E3 ligase: COP1

DEGRON score: 0.8567

ASA_SCORE: 64.475

COIL: 0.6773

CONS_SCORE: 0.4389

DSS_SCORE: 0.5054

HELIX: 0.1704

FCONS_SCORE: 1.1265

RIG_SCORE: 0.6662

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R184Q	TCGA-AJ-A3EK	UCEC	TCGA	EEGGEGATVPSA	DEG_COP1_1	0.25
p.P196S	TCGA-D3-A8GM	SKCM	TCGA	EEGGEGATVPSA	DEG_COP1_1	0.6752
p.A178T	TCGA-D5-6928	COAD	TCGA	EEGGEGATVPSA	DEG_COP1_1	0.0833
p.A199V	DO224768	BRCA	ICGC	EEGGEGATVPSA	DEG_COP1_1	0.3056
p.V179M	DO229542	UTCA	ICGC	EEGGEGATVPSA	DEG_COP1_1	0.1111
p.A193V	ACH-000999	Colon/Colorectal Cancer	CCLE	EEGGEGATVPSA	DEG_COP1_1	0.5825
p.A193V	ACH-002099	Bone Cancer	CCLE	EEGGEGATVPSA	DEG_COP1_1	0.5825
p.A193V	CS1	bone	COSMIC	EEGGEGATVPSA	DEG_COP1_1	0.5825
p.A193V	SNU-1040	large_intestine	COSMIC	EEGGEGATVPSA	DEG_COP1_1	0.5825
p.E208D	ACH-002026	Endometrial/Uterine Cancer	CCLE	EEGGEGATVPSA	DEG_COP1_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZN55	Zinc finger protein 574	DEG_COP1_1	187:198	EEGGEGATVPSA	COP1	0.8567	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons