DegronMD

Uniprot ID: Q96N77

Source protein: Zinc finger protein 641

Source gene: ZNF641

Class: DEG_COP1_1

Location: 163:173

E3 ligase: COP1

DEGRON score: 0.9719

ASA_SCORE: 84.5545

COIL: 0.7575

CONS_SCORE: 0.9158

DSS_SCORE: 0.5587

HELIX: 0.1653

FCONS_SCORE: 1.0379

RIG_SCORE: 0.7297

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E163G	TCGA-CR-7398	HNSC	TCGA	EGGEEQWVPDP	DEG_COP1_1	0.7199
p.E163G	DO14782	HNSC	ICGC	EGGEEQWVPDP	DEG_COP1_1	0.7199
p.D172G	DO227709	COCA	ICGC	EGGEEQWVPDP	DEG_COP1_1	0.7198
p.V170L	ACH-002256	Leukemia	CCLE	EGGEEQWVPDP	DEG_COP1_1	0.6765
p.V170L	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	EGGEEQWVPDP	DEG_COP1_1	0.6765
p.E163Q	SIDM00381	Cervical Carcinoma	GDSC	EGGEEQWVPDP	DEG_COP1_1	0.6744
p.E163Q	SKG-IIIa	cervix	COSMIC	EGGEEQWVPDP	DEG_COP1_1	0.6744
p.L162I	DO229009	LICA	ICGC	EGGEEQWVPDP	DEG_COP1_1	0.3056
p.V161L	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	EGGEEQWVPDP	DEG_COP1_1	0.2778
p.L156M	DO229006	LICA	ICGC	EGGEEQWVPDP	DEG_COP1_1	0.1389
p.P154S	TCGA-EE-A29V	SKCM	TCGA	EGGEEQWVPDP	DEG_COP1_1	0.0833
p.P154S	DO38006	SKCM	ICGC	EGGEEQWVPDP	DEG_COP1_1	0.0833
p.P154L	SIDM00190	Melanoma	GDSC	EGGEEQWVPDP	DEG_COP1_1	0.0833
p.P154L	CP66-MEL	skin	COSMIC	EGGEEQWVPDP	DEG_COP1_1	0.0833

Showing 1 to 14 of 14 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96N77	Zinc finger protein 641	DEG_COP1_1	163:173	EGGEEQWVPDP	COP1	0.9719	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons