DegronMD

Uniprot ID: Q9NR09

Source protein: Baculoviral IAP repeat-containing protein 6

Source gene: BIRC6

Class: DEG_COP1_1

Location: 4472:4481

E3 ligase: COP1

DEGRON score: 0.9595

ASA_SCORE: 47.29

COIL: 0.1114

CONS_SCORE: 0.5997

DSS_SCORE: 0.4352

HELIX: 0.8747

FCONS_SCORE: 1.4306

RIG_SCORE: 0.8007

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E4486Q	TCGA-E7-A7PW	BLCA	TCGA	EGLTLLVPDI	DEG_COP1_1	0.1944
p.E4486Q	DO219017	BLCA	ICGC	EGLTLLVPDI	DEG_COP1_1	0.1944
p.P4464Q	TCGA-EE-A3AD	SKCM	TCGA	EGLTLLVPDI	DEG_COP1_1	0.1111
p.P4464Q	DO37707	SKCM	ICGC	EGLTLLVPDI	DEG_COP1_1	0.1111
p.L4477F	TCGA-ER-A2NH	SKCM	TCGA	EGLTLLVPDI	DEG_COP1_1	0.587
p.L4477F	DO47683	SKCM	ICGC	EGLTLLVPDI	DEG_COP1_1	0.587
p.A4490V	TCGA-HW-8320	LGG	TCGA	EGLTLLVPDI	DEG_COP1_1	0.0833
p.A4490V	TCGA-RW-A68A	PCPG	TCGA	EGLTLLVPDI	DEG_COP1_1	0.0833
p.A4490V	DO48363	BLCA	ICGC	EGLTLLVPDI	DEG_COP1_1	0.0833
p.A4490V	DO48713	LGG	ICGC	EGLTLLVPDI	DEG_COP1_1	0.0833
p.S4467F	DO50615	BOCA	ICGC	EGLTLLVPDI	DEG_COP1_1	0.1944
p.A4466V	DO225337	BRCA	ICGC	EGLTLLVPDI	DEG_COP1_1	0.1667
p.E4472K	DO234330	ESAD	ICGC	EGLTLLVPDI	DEG_COP1_1	0.7022
p.D4468H	DO46325	OV	ICGC	EGLTLLVPDI	DEG_COP1_1	0.2222
p.D4480N	SIDM00602	Gastric Carcinoma	GDSC	EGLTLLVPDI	DEG_COP1_1	0.6932
p.D4480N	ACH-000919	Gastric Cancer	CCLE	EGLTLLVPDI	DEG_COP1_1	0.6932
p.D4480N	IM-95	stomach	COSMIC	EGLTLLVPDI	DEG_COP1_1	0.6932
p.E4472Q	ACH-002042	Thyroid Cancer	CCLE	EGLTLLVPDI	DEG_COP1_1	0.6744

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NR09	Baculoviral IAP repeat-containing protein 6	DEG_COP1_1	4472:4481	EGLTLLVPDI	COP1	0.9595	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons