DegronMD

Uniprot ID: P00519

Source protein: Tyrosine-protein kinase ABL1

Source gene: ABL1

Class: DEG_COP1_1

Location: 540:550

E3 ligase: COP1

DEGRON score: 0.8875

ASA_SCORE: 102.3636

COIL: 0.8656

CONS_SCORE: 0.3491

DSS_SCORE: 0.8131

HELIX: 0.1137

FCONS_SCORE: 0.8699

RIG_SCORE: 0.6221

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R535H	TCGA-AX-A063	UCEC	TCGA	EHRDTTDVPEM	DEG_COP1_1	0.6389
p.P548S	TCGA-AX-A2HD	UCEC	TCGA	EHRDTTDVPEM	DEG_COP1_1	0.6752
p.R552S	TCGA-BA-A6DD	HNSC	TCGA	EHRDTTDVPEM	DEG_COP1_1	0.2778
p.V534I	TCGA-HU-8602	STAD	TCGA	EHRDTTDVPEM	DEG_COP1_1	0.1667
p.R533S	DO44452	HNSC	ICGC	EHRDTTDVPEM	DEG_COP1_1	0.1389
p.E549Q	DO45454	LUSC	ICGC	EHRDTTDVPEM	DEG_COP1_1	0.6744
p.P551L	DO37415	SKCM	ICGC	EHRDTTDVPEM	DEG_COP1_1	0.3056
p.E546K	SIDM00598	Squamous Cell Lung Carcinoma	GDSC	EHRDTTDVPEM	DEG_COP1_1	0.7022
p.E546K	HARA	lung	COSMIC	EHRDTTDVPEM	DEG_COP1_1	0.7022
p.K550N	SIDM01776	Plasma Cell Myeloma	GDSC	EHRDTTDVPEM	DEG_COP1_1	0.6918
p.H552R	ACH-000914	Lymphoma	CCLE	EHRDTTDVPEM	DEG_COP1_1	0.2778
p.H552R	HT	haematopoietic_and_lymphoid_tissue	COSMIC	EHRDTTDVPEM	DEG_COP1_1	0.2778
p.K531N	ACH-001162	Myeloma	CCLE	EHRDTTDVPEM	DEG_COP1_1	0.1944

Drug responses associated with ABL1 mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
ACH-000809	Esophageal Cancer	p.K87E (No)	CCLE	Nilotinib	5.1288
ACH-000809	Esophageal Cancer	p.K87E (No)	CCLE	AZD0530	8
ACH-000445	Brain Cancer	p.N96S (No)	CCLE	Nilotinib	8
ACH-000445	Brain Cancer	p.N96S (No)	CCLE	AZD0530	8
ACH-000573	Breast Cancer	p.C100G (No)	CCLE	Nilotinib	8
ACH-000573	Breast Cancer	p.C100G (No)	CCLE	AZD0530	8
ACH-000994	Endometrial/Uterine Cancer	p.S164L (No)	CCLE	Nilotinib	8
ACH-000994	Endometrial/Uterine Cancer	p.S164L (No)	CCLE	AZD0530	8
ACH-000973	Bladder Cancer	p.Y215H (No)	CCLE	Nilotinib	8
ACH-000973	Bladder Cancer	p.Y215H (No)	CCLE	AZD0530	8
ACH-000971	Colon/Colorectal Cancer	p.Y257C (No)	CCLE	Nilotinib	8
ACH-000971	Colon/Colorectal Cancer	p.Y257C (No)	CCLE	AZD0530	8
ACH-000588	Myeloma	p.E275K (No)	CCLE	Nilotinib	6.0013
ACH-000588	Myeloma	p.E275K (No)	CCLE	AZD0530	8
ACH-000994	Endometrial/Uterine Cancer	p.M290V (No)	CCLE	Nilotinib	8
ACH-000994	Endometrial/Uterine Cancer	p.M290V (No)	CCLE	AZD0530	8
ACH-000434	Lung Cancer	p.R332W (No)	CCLE	Nilotinib	8
ACH-000434	Lung Cancer	p.R332W (No)	CCLE	AZD0530	8
ACH-000832	Head and Neck Cancer	p.P441L (No)	CCLE	AZD0530	1.1805
ACH-000994	Endometrial/Uterine Cancer	p.W476* (No)	CCLE	Nilotinib	8
ACH-000994	Endometrial/Uterine Cancer	p.W476* (No)	CCLE	AZD0530	8
ACH-000843	Lung Cancer	p.E527K (No)	CCLE	AZD0530	8
ACH-000914	Lymphoma	p.H552R (Yes)	CCLE	Nilotinib	8
ACH-000914	Lymphoma	p.H552R (Yes)	CCLE	AZD0530	8
ACH-000646	Ovarian Cancer	p.R639Q (No)	CCLE	Nilotinib	8
ACH-000646	Ovarian Cancer	p.R639Q (No)	CCLE	AZD0530	3.4851
ACH-000919	Gastric Cancer	p.P662L (No)	CCLE	Nilotinib	8
ACH-000919	Gastric Cancer	p.P662L (No)	CCLE	AZD0530	8
ACH-000753	Bladder Cancer	p.P669S (No)	CCLE	Nilotinib	5.0116
ACH-000753	Bladder Cancer	p.P669S (No)	CCLE	AZD0530	8
ACH-000943	Colon/Colorectal Cancer	p.F747I (No)	CCLE	Nilotinib	8
ACH-000943	Colon/Colorectal Cancer	p.F747I (No)	CCLE	AZD0530	8
ACH-000756	Brain Cancer	p.G753V (No)	CCLE	AZD0530	8
ACH-000984	Endometrial/Uterine Cancer	p.P782S (No)	CCLE	Nilotinib	2.0399
ACH-000984	Endometrial/Uterine Cancer	p.P782S (No)	CCLE	AZD0530	8
ACH-000966	Ovarian Cancer	p.P784fs (No)	CCLE	Nilotinib	8
ACH-000966	Ovarian Cancer	p.P784fs (No)	CCLE	AZD0530	0.7612
ACH-000983	Leukemia	p.E791G (No)	CCLE	Nilotinib	0.0137
ACH-000983	Leukemia	p.E791G (No)	CCLE	AZD0530	0.5514
ACH-000851	Lung Cancer	p.T814A (No)	CCLE	AZD0530	8
ACH-000988	Endometrial/Uterine Cancer	p.A825V (No)	CCLE	AZD0530	0.0217
ACH-000445	Brain Cancer	p.R876G (No)	CCLE	Nilotinib	8
ACH-000445	Brain Cancer	p.R876G (No)	CCLE	AZD0530	8
ACH-000961	Endometrial/Uterine Cancer	p.P900S (No)	CCLE	AZD0530	8
ACH-000963	Colon/Colorectal Cancer	p.P900S (No)	CCLE	AZD0530	0.6765
ACH-000963	Colon/Colorectal Cancer	p.A922V (No)	CCLE	AZD0530	0.6765
ACH-000579	Skin Cancer	p.P951S (No)	CCLE	AZD0530	8
ACH-000579	Skin Cancer	p.P951L (No)	CCLE	AZD0530	8
ACH-000946	Endometrial/Uterine Cancer	p.S1024N (No)	CCLE	Nilotinib	8
ACH-000946	Endometrial/Uterine Cancer	p.S1024N (No)	CCLE	AZD0530	8
ACH-000580	Skin Cancer	p.A1026T (No)	CCLE	Nilotinib	8
ACH-000580	Skin Cancer	p.A1026T (No)	CCLE	AZD0530	8
ACH-000946	Endometrial/Uterine Cancer	p.N1046S (No)	CCLE	Nilotinib	8
ACH-000946	Endometrial/Uterine Cancer	p.N1046S (No)	CCLE	AZD0530	8
ACH-000107	Pancreatic Cancer	p.G1060D (No)	CCLE	Nilotinib	0.0629
ACH-000107	Pancreatic Cancer	p.G1060D (No)	CCLE	AZD0530	1.1036
ACH-000190	Lymphoma	p.I1127T (No)	CCLE	AZD0530	8
ACH-000790	Lung Cancer	p.V1128E (No)	CCLE	Nilotinib	8
ACH-000790	Lung Cancer	p.V1128E (No)	CCLE	AZD0530	8
SIDM00213	THCA\|thyroid	p.P829L (No)	GDSC	Ponatinib	7.5816
SIDM00213	THCA\|thyroid	p.P829L (No)	GDSC	Nilotinib	29.355
SIDM00213	THCA\|thyroid	p.P829L (No)	GDSC	Bosutinib	8.2362
SIDM00213	THCA\|thyroid	p.P829L (No)	GDSC	Nilotinib	8.5463
SIDM00213	THCA\|thyroid	p.P829L (No)	GDSC	Dasatinib	11.504
SIDM00189	SKCM\|melanoma	p.G1044D (No)	GDSC	Imatinib	34.0987
SIDM00189	SKCM\|melanoma	p.G1044D (No)	GDSC	Saracatinib	32.7652
SIDM00189	SKCM\|melanoma	p.G1044D (No)	GDSC	Dasatinib	0.252
SIDM01063	UNCLASSIFIED\|Hodgkin_lymphoma	p.I1146T (No)	GDSC	Imatinib	21.4341
SIDM01063	UNCLASSIFIED\|Hodgkin_lymphoma	p.I1146T (No)	GDSC	Saracatinib	13.7046
SIDM01063	UNCLASSIFIED\|Hodgkin_lymphoma	p.I1146T (No)	GDSC	Dasatinib	3.1241
SIDM01063	UNCLASSIFIED\|Hodgkin_lymphoma	p.I1146T (No)	GDSC	Ponatinib	5.2697
SIDM01063	UNCLASSIFIED\|Hodgkin_lymphoma	p.I1146T (No)	GDSC	Nilotinib	5.6016
SIDM01063	UNCLASSIFIED\|Hodgkin_lymphoma	p.I1146T (No)	GDSC	Bosutinib	1.5956
SIDM01063	UNCLASSIFIED\|Hodgkin_lymphoma	p.I1146T (No)	GDSC	Nilotinib	605.57
SIDM01063	UNCLASSIFIED\|Hodgkin_lymphoma	p.I1146T (No)	GDSC	Dasatinib	331.1
SIDM01004	LCML\|chronic_myeloid_leukaemia	p.E810G (No)	GDSC	Imatinib	0.1788
SIDM01004	LCML\|chronic_myeloid_leukaemia	p.E810G (No)	GDSC	Saracatinib	0.4925
SIDM01004	LCML\|chronic_myeloid_leukaemia	p.E810G (No)	GDSC	Dasatinib	0.0017
SIDM01004	LCML\|chronic_myeloid_leukaemia	p.E810G (No)	GDSC	Ponatinib	0.0014
SIDM01004	LCML\|chronic_myeloid_leukaemia	p.E810G (No)	GDSC	Nilotinib	0.0168
SIDM01004	LCML\|chronic_myeloid_leukaemia	p.E810G (No)	GDSC	Bosutinib	1.3084
SIDM01004	LCML\|chronic_myeloid_leukaemia	p.E810G (No)	GDSC	Nilotinib	0.0198
SIDM01004	LCML\|chronic_myeloid_leukaemia	p.E810G (No)	GDSC	Dasatinib	0.001
SIDM00629	BRCA\|breast	p.C119G (No)	GDSC	Ponatinib	13.8061
SIDM00629	BRCA\|breast	p.C119G (No)	GDSC	Nilotinib	56.4933
SIDM00629	BRCA\|breast	p.C119G (No)	GDSC	Bosutinib	12.2232
SIDM00629	BRCA\|breast	p.C119G (No)	GDSC	Nilotinib	38.49
SIDM00629	BRCA\|breast	p.C119G (No)	GDSC	Dasatinib	80.481
SIDM00661	DLBC\|B_cell_lymphoma	p.H571R (No)	GDSC	Imatinib	22.6084
SIDM00661	DLBC\|B_cell_lymphoma	p.H571R (No)	GDSC	Saracatinib	22.6084
SIDM00661	DLBC\|B_cell_lymphoma	p.H571R (No)	GDSC	Dasatinib	7.4817
SIDM00661	DLBC\|B_cell_lymphoma	p.H571R (No)	GDSC	Ponatinib	5.3173
SIDM00661	DLBC\|B_cell_lymphoma	p.H571R (No)	GDSC	Nilotinib	17.9504
SIDM00661	DLBC\|B_cell_lymphoma	p.H571R (No)	GDSC	Bosutinib	18.5762
SIDM00683	PRAD\|prostate	p.N789S (No)	GDSC	Imatinib	7.6142
SIDM00683	PRAD\|prostate	p.N789S (No)	GDSC	Saracatinib	34.6491
SIDM00683	PRAD\|prostate	p.N789S (No)	GDSC	Dasatinib	21.2398
SIDM00683	PRAD\|prostate	p.N789S (No)	GDSC	Ponatinib	3.947
SIDM00683	PRAD\|prostate	p.N789S (No)	GDSC	Nilotinib	16.6512
SIDM00683	PRAD\|prostate	p.N789S (No)	GDSC	Bosutinib	27.1251
SIDM00683	PRAD\|prostate	p.N789S (No)	GDSC	Nilotinib	5.1124
SIDM00683	PRAD\|prostate	p.N789S (No)	GDSC	Dasatinib	11.862
SIDM00108	SKCM\|melanoma	p.P970S (No)	GDSC	Imatinib	27.0124
SIDM00108	SKCM\|melanoma	p.P970S (No)	GDSC	Saracatinib	22.0925
SIDM00108	SKCM\|melanoma	p.P970S (No)	GDSC	Dasatinib	4.7849
SIDM00108	SKCM\|melanoma	p.P970S (No)	GDSC	Ponatinib	6.2969
SIDM00108	SKCM\|melanoma	p.P970S (No)	GDSC	Nilotinib	26.5156
SIDM00108	SKCM\|melanoma	p.P970S (No)	GDSC	Bosutinib	25.7167
SIDM00108	SKCM\|melanoma	p.P970S (No)	GDSC	Nilotinib	44.509
SIDM00108	SKCM\|melanoma	p.P970S (No)	GDSC	Dasatinib	24.321
SIDM00108	SKCM\|melanoma	p.P970L (No)	GDSC	Imatinib	27.0124
SIDM00108	SKCM\|melanoma	p.P970L (No)	GDSC	Saracatinib	22.0925
SIDM00108	SKCM\|melanoma	p.P970L (No)	GDSC	Dasatinib	4.7849
SIDM00108	SKCM\|melanoma	p.P970L (No)	GDSC	Ponatinib	6.2969
SIDM00108	SKCM\|melanoma	p.P970L (No)	GDSC	Nilotinib	26.5156
SIDM00108	SKCM\|melanoma	p.P970L (No)	GDSC	Bosutinib	25.7167
SIDM00108	SKCM\|melanoma	p.P970L (No)	GDSC	Nilotinib	44.509
SIDM00108	SKCM\|melanoma	p.P970L (No)	GDSC	Dasatinib	24.321
SIDM00937	HNSC\|head_and_neck	p.P460L (No)	GDSC	Ponatinib	5.7252
SIDM00937	HNSC\|head_and_neck	p.P460L (No)	GDSC	Nilotinib	9.5153
SIDM00937	HNSC\|head_and_neck	p.P460L (No)	GDSC	Bosutinib	0.7821
SIDM00937	HNSC\|head_and_neck	p.P460L (No)	GDSC	Nilotinib	63.863
SIDM00937	HNSC\|head_and_neck	p.P460L (No)	GDSC	Dasatinib	0.6476
SIDM00224	MESO\|mesothelioma	p.P829L (No)	GDSC	Imatinib	30.0665
SIDM00224	MESO\|mesothelioma	p.P829L (No)	GDSC	Saracatinib	3.8183
SIDM00224	MESO\|mesothelioma	p.P829L (No)	GDSC	Dasatinib	0.0758
SIDM00224	MESO\|mesothelioma	p.P829L (No)	GDSC	Ponatinib	0.2064
SIDM00224	MESO\|mesothelioma	p.P829L (No)	GDSC	Nilotinib	11.5883
SIDM00224	MESO\|mesothelioma	p.P829L (No)	GDSC	Bosutinib	30.4323
SIDM00224	MESO\|mesothelioma	p.P829L (No)	GDSC	Nilotinib	139.61
SIDM00224	MESO\|mesothelioma	p.P829L (No)	GDSC	Dasatinib	0.4822
SIDM01078	SCLC\|lung_small_cell_carcinoma	p.V1147E (No)	GDSC	Imatinib	7.0465
SIDM01078	SCLC\|lung_small_cell_carcinoma	p.V1147E (No)	GDSC	Saracatinib	6.9327
SIDM01078	SCLC\|lung_small_cell_carcinoma	p.V1147E (No)	GDSC	Dasatinib	9.295
SIDM01078	SCLC\|lung_small_cell_carcinoma	p.V1147E (No)	GDSC	Ponatinib	3.0818
SIDM01078	SCLC\|lung_small_cell_carcinoma	p.V1147E (No)	GDSC	Nilotinib	19.2011
SIDM01078	SCLC\|lung_small_cell_carcinoma	p.V1147E (No)	GDSC	Bosutinib	17.5855
SIDM01078	SCLC\|lung_small_cell_carcinoma	p.V1147E (No)	GDSC	Nilotinib	5.5348
SIDM01078	SCLC\|lung_small_cell_carcinoma	p.V1147E (No)	GDSC	Dasatinib	28.96
SIDM00669	PAAD\|pancreas	p.P829L (No)	GDSC	Ponatinib	0.3787
SIDM00669	PAAD\|pancreas	p.P829L (No)	GDSC	Nilotinib	38.3601
SIDM00669	PAAD\|pancreas	p.P829L (No)	GDSC	Bosutinib	14.6104
SIDM00669	PAAD\|pancreas	p.P829L (No)	GDSC	Nilotinib	96.439
SIDM00669	PAAD\|pancreas	p.P829L (No)	GDSC	Dasatinib	8.1022
SIDM00664	PAAD\|pancreas	p.R608H (No)	GDSC	Ponatinib	3.3793
SIDM00664	PAAD\|pancreas	p.R608H (No)	GDSC	Nilotinib	12.459
SIDM00664	PAAD\|pancreas	p.R608H (No)	GDSC	Bosutinib	2.7762
SIDM00664	PAAD\|pancreas	p.R608H (No)	GDSC	Nilotinib	72.987
SIDM00664	PAAD\|pancreas	p.R608H (No)	GDSC	Dasatinib	5.2866
SIDM00381	CESC\|cervix	p.A846S (No)	GDSC	Ponatinib	7.182
SIDM00381	CESC\|cervix	p.A846S (No)	GDSC	Nilotinib	76.8649
SIDM00381	CESC\|cervix	p.A846S (No)	GDSC	Bosutinib	26.491
SIDM00381	CESC\|cervix	p.A846S (No)	GDSC	Nilotinib	24.774
SIDM00381	CESC\|cervix	p.A846S (No)	GDSC	Dasatinib	0.7739
SIDM00591	HNSC\|head_and_neck	p.R153C (No)	GDSC	Ponatinib	3.0724
SIDM00591	HNSC\|head_and_neck	p.R153C (No)	GDSC	Nilotinib	7.1112
SIDM00591	HNSC\|head_and_neck	p.R153C (No)	GDSC	Bosutinib	2.8089
SIDM00591	HNSC\|head_and_neck	p.R153C (No)	GDSC	Nilotinib	4.4213
SIDM00591	HNSC\|head_and_neck	p.R153C (No)	GDSC	Dasatinib	0.3335
SIDM00393	STAD\|stomach	p.T243I (No)	GDSC	Nilotinib	14.7574
SIDM00393	STAD\|stomach	p.T243I (No)	GDSC	Bosutinib	1.1488
SIDM00393	STAD\|stomach	p.T243I (No)	GDSC	Nilotinib	22.995
SIDM00393	STAD\|stomach	p.T243I (No)	GDSC	Dasatinib	0.5865
SIDM00943	PAAD\|pancreas	p.G1079D (No)	GDSC	Ponatinib	5.2959
SIDM00943	PAAD\|pancreas	p.G1079D (No)	GDSC	Nilotinib	54.6566
SIDM00943	PAAD\|pancreas	p.G1079D (No)	GDSC	Bosutinib	55.356
SIDM00943	PAAD\|pancreas	p.G1079D (No)	GDSC	Nilotinib	417.69
SIDM00943	PAAD\|pancreas	p.G1079D (No)	GDSC	Dasatinib	0.2994
SIDM00251	STAD\|stomach	p.G720S (No)	GDSC	Ponatinib	5.6088
SIDM00251	STAD\|stomach	p.G720S (No)	GDSC	Nilotinib	9.9916
SIDM00251	STAD\|stomach	p.G720S (No)	GDSC	Bosutinib	8.9003
SIDM00251	STAD\|stomach	p.G720S (No)	GDSC	Nilotinib	42.713
SIDM00251	STAD\|stomach	p.G720S (No)	GDSC	Dasatinib	24.196
SIDM00251	STAD\|stomach	p.E890K (No)	GDSC	Ponatinib	5.6088
SIDM00251	STAD\|stomach	p.E890K (No)	GDSC	Nilotinib	9.9916
SIDM00251	STAD\|stomach	p.E890K (No)	GDSC	Bosutinib	8.9003
SIDM00251	STAD\|stomach	p.E890K (No)	GDSC	Nilotinib	42.713
SIDM00251	STAD\|stomach	p.E890K (No)	GDSC	Dasatinib	24.196
SIDM01090	COREAD\|large_intestine	p.F766I (No)	GDSC	Imatinib	19.0757
SIDM01090	COREAD\|large_intestine	p.F766I (No)	GDSC	Saracatinib	13.6546
SIDM01090	COREAD\|large_intestine	p.F766I (No)	GDSC	Dasatinib	0.398
SIDM01090	COREAD\|large_intestine	p.F766I (No)	GDSC	Ponatinib	1.11
SIDM01090	COREAD\|large_intestine	p.F766I (No)	GDSC	Nilotinib	5.0496
SIDM01090	COREAD\|large_intestine	p.F766I (No)	GDSC	Bosutinib	11.2427
SIDM01090	COREAD\|large_intestine	p.F766I (No)	GDSC	Nilotinib	5.9646
SIDM01090	COREAD\|large_intestine	p.F766I (No)	GDSC	Dasatinib	6.118
SIDM00516	SKCM\|melanoma	p.R185K (No)	GDSC	Imatinib	17.9874
SIDM00516	SKCM\|melanoma	p.R185K (No)	GDSC	Saracatinib	28.8907
SIDM00516	SKCM\|melanoma	p.R185K (No)	GDSC	Dasatinib	0.296
SIDM00516	SKCM\|melanoma	p.R185K (No)	GDSC	Ponatinib	2.323
SIDM00516	SKCM\|melanoma	p.R185K (No)	GDSC	Nilotinib	12.9886
SIDM00516	SKCM\|melanoma	p.R185K (No)	GDSC	Bosutinib	23.3431
SIDM00907	UNCLASSIFIED\|Burkitt_lymphoma	p.V587M (No)	GDSC	Imatinib	21.8954
SIDM00907	UNCLASSIFIED\|Burkitt_lymphoma	p.V587M (No)	GDSC	Saracatinib	10.9873
SIDM00907	UNCLASSIFIED\|Burkitt_lymphoma	p.V587M (No)	GDSC	Dasatinib	2.9394
SIDM00907	UNCLASSIFIED\|Burkitt_lymphoma	p.V587M (No)	GDSC	Ponatinib	0.1275
SIDM00907	UNCLASSIFIED\|Burkitt_lymphoma	p.V587M (No)	GDSC	Nilotinib	28.4004
SIDM00907	UNCLASSIFIED\|Burkitt_lymphoma	p.V587M (No)	GDSC	Bosutinib	11.8456
SIDM00907	UNCLASSIFIED\|Burkitt_lymphoma	p.V587M (No)	GDSC	Nilotinib	12.353
SIDM00907	UNCLASSIFIED\|Burkitt_lymphoma	p.V587M (No)	GDSC	Dasatinib	0.9106
SIDM00151	OV\|ovary	p.R804fs*3 (No)	GDSC	Nilotinib	53.508
SIDM00151	OV\|ovary	p.R804fs*3 (No)	GDSC	Bosutinib	0.5623
SIDM00151	OV\|ovary	p.R804fs*3 (No)	GDSC	Nilotinib	77.517
SIDM00151	OV\|ovary	p.R804fs*3 (No)	GDSC	Dasatinib	0.0537
SIDM00482	LCML\|chronic_myeloid_leukaemia	p.P131S (No)	GDSC	Imatinib	20.3906
SIDM00482	LCML\|chronic_myeloid_leukaemia	p.P131S (No)	GDSC	Saracatinib	23.7883
SIDM00482	LCML\|chronic_myeloid_leukaemia	p.P131S (No)	GDSC	Dasatinib	2.1819
SIDM00482	LCML\|chronic_myeloid_leukaemia	p.P131S (No)	GDSC	Ponatinib	4.7966
SIDM00482	LCML\|chronic_myeloid_leukaemia	p.P131S (No)	GDSC	Nilotinib	3.6021
SIDM00482	LCML\|chronic_myeloid_leukaemia	p.P131S (No)	GDSC	Bosutinib	0.5976
SIDM00482	LCML\|chronic_myeloid_leukaemia	p.P131S (No)	GDSC	Dasatinib	0.8259
SIDM00488	COREAD\|large_intestine	p.N115S (No)	GDSC	Ponatinib	15.2626
SIDM00488	COREAD\|large_intestine	p.N115S (No)	GDSC	Nilotinib	37.456
SIDM00488	COREAD\|large_intestine	p.N115S (No)	GDSC	Bosutinib	6.7991
SIDM00488	COREAD\|large_intestine	p.N115S (No)	GDSC	Nilotinib	95.088
SIDM00488	COREAD\|large_intestine	p.N115S (No)	GDSC	Dasatinib	0.36
SIDM00488	COREAD\|large_intestine	p.R895G (No)	GDSC	Ponatinib	15.2626
SIDM00488	COREAD\|large_intestine	p.R895G (No)	GDSC	Nilotinib	37.456
SIDM00488	COREAD\|large_intestine	p.R895G (No)	GDSC	Bosutinib	6.7991
SIDM00488	COREAD\|large_intestine	p.R895G (No)	GDSC	Nilotinib	95.088
SIDM00488	COREAD\|large_intestine	p.R895G (No)	GDSC	Dasatinib	0.36
SIDM00602	STAD\|stomach	p.P681L (No)	GDSC	Ponatinib	1.0217
SIDM00602	STAD\|stomach	p.P681L (No)	GDSC	Nilotinib	12.5319
SIDM00602	STAD\|stomach	p.P681L (No)	GDSC	Bosutinib	11.5105
SIDM00602	STAD\|stomach	p.P681L (No)	GDSC	Nilotinib	74.547
SIDM00602	STAD\|stomach	p.P681L (No)	GDSC	Dasatinib	64.078
SIDM00577	NB\|neuroblastoma	p.A666D (No)	GDSC	Imatinib	30.9572
SIDM00577	NB\|neuroblastoma	p.A666D (No)	GDSC	Saracatinib	29.8267
SIDM00577	NB\|neuroblastoma	p.A666D (No)	GDSC	Dasatinib	19.5207
SIDM00577	NB\|neuroblastoma	p.A666D (No)	GDSC	Ponatinib	0.5561
SIDM00577	NB\|neuroblastoma	p.A666D (No)	GDSC	Nilotinib	29.6826
SIDM00577	NB\|neuroblastoma	p.A666D (No)	GDSC	Bosutinib	10.0095
SIDM00577	NB\|neuroblastoma	p.A666D (No)	GDSC	Nilotinib	122.33
SIDM00577	NB\|neuroblastoma	p.A666D (No)	GDSC	Dasatinib	90.238
SIDM00258	NB\|neuroblastoma	p.K915N (No)	GDSC	Ponatinib	1.7574
SIDM00258	NB\|neuroblastoma	p.K915N (No)	GDSC	Nilotinib	31.0453
SIDM00258	NB\|neuroblastoma	p.K915N (No)	GDSC	Bosutinib	28.0105
SIDM00258	NB\|neuroblastoma	p.K915N (No)	GDSC	Nilotinib	13.516
SIDM00258	NB\|neuroblastoma	p.K915N (No)	GDSC	Dasatinib	26.961
SIDM01028	ESCA\|oesophagus	p.K106E (No)	GDSC	Ponatinib	0.5687
SIDM01028	ESCA\|oesophagus	p.K106E (No)	GDSC	Nilotinib	29.8309
SIDM01028	ESCA\|oesophagus	p.K106E (No)	GDSC	Bosutinib	1.5131
SIDM01028	ESCA\|oesophagus	p.K106E (No)	GDSC	Nilotinib	230.24
SIDM01028	ESCA\|oesophagus	p.K106E (No)	GDSC	Dasatinib	2.2175
SIDM01092	STAD\|stomach	p.R649H (No)	GDSC	Imatinib	30.3559
SIDM01092	STAD\|stomach	p.R649H (No)	GDSC	Saracatinib	6.711
SIDM01092	STAD\|stomach	p.R649H (No)	GDSC	Dasatinib	1.1025
SIDM01092	STAD\|stomach	p.R649H (No)	GDSC	Ponatinib	0.5733
SIDM01092	STAD\|stomach	p.R649H (No)	GDSC	Nilotinib	12.664
SIDM01092	STAD\|stomach	p.R649H (No)	GDSC	Bosutinib	3.6028
SIDM01092	STAD\|stomach	p.R649H (No)	GDSC	Nilotinib	46.883
SIDM01092	STAD\|stomach	p.R649H (No)	GDSC	Dasatinib	3.4925
SIDM00333	UCEC\|endometrium	p.P829L (No)	GDSC	Ponatinib	1.1816
SIDM00333	UCEC\|endometrium	p.P829L (No)	GDSC	Nilotinib	16.8693
SIDM00333	UCEC\|endometrium	p.P829L (No)	GDSC	Bosutinib	9.7868
SIDM00333	UCEC\|endometrium	p.P829L (No)	GDSC	Nilotinib	66.66
SIDM00333	UCEC\|endometrium	p.P829L (No)	GDSC	Dasatinib	12.799
SIDM00333	UCEC\|endometrium	p.A844V (No)	GDSC	Ponatinib	1.1816
SIDM00333	UCEC\|endometrium	p.A844V (No)	GDSC	Nilotinib	16.8693
SIDM00333	UCEC\|endometrium	p.A844V (No)	GDSC	Bosutinib	9.7868
SIDM00333	UCEC\|endometrium	p.A844V (No)	GDSC	Nilotinib	66.66
SIDM00333	UCEC\|endometrium	p.A844V (No)	GDSC	Dasatinib	12.799
SIDM00598	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.E546K (Yes)	GDSC	Ponatinib	1.7349
SIDM00598	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.E546K (Yes)	GDSC	Nilotinib	6.352
SIDM00598	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.E546K (Yes)	GDSC	Bosutinib	0.8214
SIDM00598	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.E546K (Yes)	GDSC	Nilotinib	9.0412
SIDM00598	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.E546K (Yes)	GDSC	Dasatinib	1.3473
SIDM00256	NB\|neuroblastoma	p.P829L (No)	GDSC	Imatinib	14.3579
SIDM00256	NB\|neuroblastoma	p.P829L (No)	GDSC	Saracatinib	10.6651
SIDM00256	NB\|neuroblastoma	p.P829L (No)	GDSC	Dasatinib	12.2387
SIDM00256	NB\|neuroblastoma	p.P829L (No)	GDSC	Ponatinib	3.2515
SIDM00256	NB\|neuroblastoma	p.P829L (No)	GDSC	Nilotinib	10.612
SIDM00256	NB\|neuroblastoma	p.P829L (No)	GDSC	Bosutinib	7.7999
SIDM00256	NB\|neuroblastoma	p.P829L (No)	GDSC	Nilotinib	6.1217
SIDM00256	NB\|neuroblastoma	p.P829L (No)	GDSC	Dasatinib	18.539
SIDM01199	LIHC\|liver	p.H415Q (No)	GDSC	Ponatinib	3.6123
SIDM01199	LIHC\|liver	p.H415Q (No)	GDSC	Nilotinib	14.9169
SIDM01199	LIHC\|liver	p.H415Q (No)	GDSC	Bosutinib	24.8986
SIDM01199	LIHC\|liver	p.H415Q (No)	GDSC	Nilotinib	100.34
SIDM01199	LIHC\|liver	p.H415Q (No)	GDSC	Dasatinib	0.8905
SIDM00140	SKCM\|melanoma	p.T719I (No)	GDSC	Ponatinib	5.6195
SIDM00140	SKCM\|melanoma	p.T719I (No)	GDSC	Nilotinib	36.9507
SIDM00140	SKCM\|melanoma	p.T719I (No)	GDSC	Bosutinib	6.3453
SIDM00140	SKCM\|melanoma	p.T719I (No)	GDSC	Nilotinib	67.004
SIDM00140	SKCM\|melanoma	p.T719I (No)	GDSC	Dasatinib	54.529
SIDM00948	UNCLASSIFIED\|Burkitt_lymphoma	p.A156T (No)	GDSC	Imatinib	28.2456
SIDM00948	UNCLASSIFIED\|Burkitt_lymphoma	p.A156T (No)	GDSC	Saracatinib	28.2456
SIDM00948	UNCLASSIFIED\|Burkitt_lymphoma	p.A156T (No)	GDSC	Dasatinib	2.339
SIDM00948	UNCLASSIFIED\|Burkitt_lymphoma	p.A156T (No)	GDSC	Ponatinib	7.2309
SIDM00948	UNCLASSIFIED\|Burkitt_lymphoma	p.A156T (No)	GDSC	Nilotinib	21.6398
SIDM00948	UNCLASSIFIED\|Burkitt_lymphoma	p.A156T (No)	GDSC	Bosutinib	4.1634
SIDM00948	UNCLASSIFIED\|Burkitt_lymphoma	p.A156T (No)	GDSC	Nilotinib	17.611
SIDM00948	UNCLASSIFIED\|Burkitt_lymphoma	p.A156T (No)	GDSC	Dasatinib	2.7968
SIDM00216	COREAD\|large_intestine	p.R839W (No)	GDSC	Nilotinib	39.635
SIDM00216	COREAD\|large_intestine	p.R839W (No)	GDSC	Dasatinib	11.384
SIDM00344	UNCLASSIFIED\|lung_NSCLC_large_cell	p.P829L (No)	GDSC	Ponatinib	0.4167
SIDM00344	UNCLASSIFIED\|lung_NSCLC_large_cell	p.P829L (No)	GDSC	Nilotinib	12.7375
SIDM00344	UNCLASSIFIED\|lung_NSCLC_large_cell	p.P829L (No)	GDSC	Bosutinib	7.2686
SIDM00344	UNCLASSIFIED\|lung_NSCLC_large_cell	p.P829L (No)	GDSC	Nilotinib	44.488
SIDM00344	UNCLASSIFIED\|lung_NSCLC_large_cell	p.P829L (No)	GDSC	Dasatinib	36.084
SIDM00596	UCEC\|endometrium	p.R502W (No)	GDSC	Ponatinib	1.0474
SIDM00596	UCEC\|endometrium	p.R502W (No)	GDSC	Nilotinib	4.4301
SIDM00596	UCEC\|endometrium	p.R502W (No)	GDSC	Bosutinib	6.3239
SIDM00596	UCEC\|endometrium	p.R502W (No)	GDSC	Nilotinib	100.63
SIDM00596	UCEC\|endometrium	p.R502W (No)	GDSC	Dasatinib	24.115
SIDM00888	MB\|medulloblastoma	p.A988T (No)	GDSC	Imatinib	17.1814
SIDM00888	MB\|medulloblastoma	p.A988T (No)	GDSC	Saracatinib	7.1883
SIDM00888	MB\|medulloblastoma	p.A988T (No)	GDSC	Dasatinib	2.8208
SIDM00888	MB\|medulloblastoma	p.A988T (No)	GDSC	Ponatinib	5.3797
SIDM00888	MB\|medulloblastoma	p.A988T (No)	GDSC	Nilotinib	27.2806
SIDM00888	MB\|medulloblastoma	p.A988T (No)	GDSC	Bosutinib	18.6769
SIDM00888	MB\|medulloblastoma	p.A988T (No)	GDSC	Nilotinib	13.479
SIDM00888	MB\|medulloblastoma	p.A988T (No)	GDSC	Dasatinib	4.1606
SIDM00763	UNCLASSIFIED\|lung_NSCLC_large_cell	p.R351W (No)	GDSC	Ponatinib	3.4514
SIDM00763	UNCLASSIFIED\|lung_NSCLC_large_cell	p.R351W (No)	GDSC	Nilotinib	27.0036
SIDM00763	UNCLASSIFIED\|lung_NSCLC_large_cell	p.R351W (No)	GDSC	Bosutinib	28.6195
SIDM00763	UNCLASSIFIED\|lung_NSCLC_large_cell	p.R351W (No)	GDSC	Nilotinib	36.126
SIDM00763	UNCLASSIFIED\|lung_NSCLC_large_cell	p.R351W (No)	GDSC	Dasatinib	6.1436
SIDM00783	COREAD\|large_intestine	p.Y276C (No)	GDSC	Ponatinib	0.2316
SIDM00783	COREAD\|large_intestine	p.Y276C (No)	GDSC	Nilotinib	5.6714
SIDM00783	COREAD\|large_intestine	p.Y276C (No)	GDSC	Bosutinib	1.5957
SIDM00783	COREAD\|large_intestine	p.Y276C (No)	GDSC	Nilotinib	8.5519
SIDM00783	COREAD\|large_intestine	p.Y276C (No)	GDSC	Dasatinib	20.176
SIDM00703	UNCLASSIFIED\|lung_NSCLC_not_specified	p.G340W (No)	GDSC	Ponatinib	2.7183
SIDM00703	UNCLASSIFIED\|lung_NSCLC_not_specified	p.G340W (No)	GDSC	Nilotinib	15.1943
SIDM00703	UNCLASSIFIED\|lung_NSCLC_not_specified	p.G340W (No)	GDSC	Bosutinib	4.6417
SIDM00703	UNCLASSIFIED\|lung_NSCLC_not_specified	p.G340V (No)	GDSC	Ponatinib	2.7183
SIDM00703	UNCLASSIFIED\|lung_NSCLC_not_specified	p.G340V (No)	GDSC	Nilotinib	15.1943
SIDM00703	UNCLASSIFIED\|lung_NSCLC_not_specified	p.G340V (No)	GDSC	Bosutinib	4.6417
SIDM00329	UNCLASSIFIED\|Hodgkin_lymphoma	p.Q1131L (No)	GDSC	Imatinib	9.4971
SIDM00329	UNCLASSIFIED\|Hodgkin_lymphoma	p.Q1131L (No)	GDSC	Saracatinib	7.0934
SIDM00329	UNCLASSIFIED\|Hodgkin_lymphoma	p.Q1131L (No)	GDSC	Dasatinib	3.5196
SIDM00329	UNCLASSIFIED\|Hodgkin_lymphoma	p.Q1131L (No)	GDSC	Ponatinib	0.6636
SIDM00329	UNCLASSIFIED\|Hodgkin_lymphoma	p.Q1131L (No)	GDSC	Nilotinib	5.0462
SIDM00329	UNCLASSIFIED\|Hodgkin_lymphoma	p.Q1131L (No)	GDSC	Bosutinib	1.2306
SIDM00329	UNCLASSIFIED\|Hodgkin_lymphoma	p.Q1131L (No)	GDSC	Nilotinib	16.572
SIDM00329	UNCLASSIFIED\|Hodgkin_lymphoma	p.Q1131L (No)	GDSC	Dasatinib	7.4495
SIDM00819	KIRC\|kidney	p.V741I (No)	GDSC	Nilotinib	26.2977
SIDM00819	KIRC\|kidney	p.V741I (No)	GDSC	Bosutinib	2.5975
SIDM00589	HNSC\|head_and_neck	p.V390I (No)	GDSC	Ponatinib	1.3941
SIDM00589	HNSC\|head_and_neck	p.V390I (No)	GDSC	Nilotinib	6.6727
SIDM00589	HNSC\|head_and_neck	p.V390I (No)	GDSC	Bosutinib	0.9409
SIDM00589	HNSC\|head_and_neck	p.V390I (No)	GDSC	Nilotinib	15.032
SIDM00589	HNSC\|head_and_neck	p.V390I (No)	GDSC	Dasatinib	0.35
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.P845S (No)	GDSC	Imatinib	11.7665
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.P845S (No)	GDSC	Saracatinib	9.4351
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.P845S (No)	GDSC	Dasatinib	0.3358
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.P845S (No)	GDSC	Ponatinib	17.9617
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.P845S (No)	GDSC	Nilotinib	84.1662
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.P845S (No)	GDSC	Bosutinib	84.1662
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.P845S (No)	GDSC	Nilotinib	393.51
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.P845S (No)	GDSC	Dasatinib	13.657
SIDM00680	COREAD\|large_intestine	p.G883fs*12 (No)	GDSC	Ponatinib	2.9188
SIDM00680	COREAD\|large_intestine	p.G883fs*12 (No)	GDSC	Nilotinib	43.2506
SIDM00680	COREAD\|large_intestine	p.G883fs*12 (No)	GDSC	Bosutinib	32.6575
SIDM00680	COREAD\|large_intestine	p.G883fs*12 (No)	GDSC	Nilotinib	38.395
SIDM00680	COREAD\|large_intestine	p.G883fs*12 (No)	GDSC	Dasatinib	91.676
SIDM00273	LGG\|glioma	p.G772V (No)	GDSC	Imatinib	18.1693
SIDM00273	LGG\|glioma	p.G772V (No)	GDSC	Saracatinib	1.4536
SIDM00273	LGG\|glioma	p.G772V (No)	GDSC	Dasatinib	0.629
SIDM00273	LGG\|glioma	p.G772V (No)	GDSC	Ponatinib	1.2325
SIDM00273	LGG\|glioma	p.G772V (No)	GDSC	Nilotinib	5.3117
SIDM00273	LGG\|glioma	p.G772V (No)	GDSC	Bosutinib	17.0982
SIDM00273	LGG\|glioma	p.G772V (No)	GDSC	Nilotinib	5.5543
SIDM00273	LGG\|glioma	p.G772V (No)	GDSC	Dasatinib	1.8506
SIDM00487	COREAD\|large_intestine	p.P919S (No)	GDSC	Ponatinib	4.8982
SIDM00487	COREAD\|large_intestine	p.P919S (No)	GDSC	Nilotinib	28.1913
SIDM00487	COREAD\|large_intestine	p.P919S (No)	GDSC	Bosutinib	2.5364
SIDM00487	COREAD\|large_intestine	p.P919S (No)	GDSC	Nilotinib	50.77
SIDM00487	COREAD\|large_intestine	p.P919S (No)	GDSC	Dasatinib	2.8765
SIDM00487	COREAD\|large_intestine	p.A941V (No)	GDSC	Ponatinib	4.8982
SIDM00487	COREAD\|large_intestine	p.A941V (No)	GDSC	Nilotinib	28.1913
SIDM00487	COREAD\|large_intestine	p.A941V (No)	GDSC	Bosutinib	2.5364
SIDM00487	COREAD\|large_intestine	p.A941V (No)	GDSC	Nilotinib	50.77
SIDM00487	COREAD\|large_intestine	p.A941V (No)	GDSC	Dasatinib	2.8765
SIDM00282	COREAD\|large_intestine	p.K527fs*12 (No)	GDSC	Imatinib	51.6867
SIDM00282	COREAD\|large_intestine	p.K527fs*12 (No)	GDSC	Saracatinib	55.2762
SIDM00282	COREAD\|large_intestine	p.K527fs*12 (No)	GDSC	Dasatinib	34.4884
SIDM00282	COREAD\|large_intestine	p.K527fs*12 (No)	GDSC	Ponatinib	13.9216
SIDM00282	COREAD\|large_intestine	p.K527fs*12 (No)	GDSC	Nilotinib	42.4131
SIDM00282	COREAD\|large_intestine	p.K527fs*12 (No)	GDSC	Bosutinib	58.7424
SIDM00282	COREAD\|large_intestine	p.K527fs*12 (No)	GDSC	Nilotinib	5.7947
SIDM00282	COREAD\|large_intestine	p.K527fs*12 (No)	GDSC	Dasatinib	11.536
SIDM00414	BLCA\|bladder	p.P933L (No)	GDSC	Ponatinib	3.0934
SIDM00414	BLCA\|bladder	p.P933L (No)	GDSC	Nilotinib	8.1334
SIDM00414	BLCA\|bladder	p.P933L (No)	GDSC	Bosutinib	5.0631
SIDM00414	BLCA\|bladder	p.P933L (No)	GDSC	Nilotinib	28.375
SIDM00414	BLCA\|bladder	p.P933L (No)	GDSC	Dasatinib	6.2651
SIDM00394	CESC\|cervix	p.N115S (No)	GDSC	Ponatinib	5.6886
SIDM00394	CESC\|cervix	p.N115S (No)	GDSC	Nilotinib	22.2542
SIDM00394	CESC\|cervix	p.N115S (No)	GDSC	Bosutinib	4.8195
SIDM00394	CESC\|cervix	p.N115S (No)	GDSC	Nilotinib	134.56
SIDM00394	CESC\|cervix	p.N115S (No)	GDSC	Dasatinib	86.642
SIDM00890	SKCM\|melanoma	p.A1045T (No)	GDSC	Ponatinib	10.6712
SIDM00890	SKCM\|melanoma	p.A1045T (No)	GDSC	Nilotinib	10.8952
SIDM00890	SKCM\|melanoma	p.A1045T (No)	GDSC	Bosutinib	20.6924
SIDM00890	SKCM\|melanoma	p.A1045T (No)	GDSC	Nilotinib	79.804
SIDM00890	SKCM\|melanoma	p.A1045T (No)	GDSC	Dasatinib	65.834
SIDM00135	BRCA\|breast	p.K7R (No)	GDSC	Ponatinib	1.7558
SIDM00135	BRCA\|breast	p.K7R (No)	GDSC	Nilotinib	26.4867
SIDM00135	BRCA\|breast	p.K7R (No)	GDSC	Bosutinib	15.9857
SIDM00135	BRCA\|breast	p.K7R (No)	GDSC	Nilotinib	3.0704
SIDM00135	BRCA\|breast	p.K7R (No)	GDSC	Dasatinib	0.0885
SIDM00537	COREAD\|large_intestine	p.N617D (No)	GDSC	Ponatinib	1.9526
SIDM00537	COREAD\|large_intestine	p.N617D (No)	GDSC	Nilotinib	5.2668
SIDM00537	COREAD\|large_intestine	p.N617D (No)	GDSC	Bosutinib	2.5114
SIDM00537	COREAD\|large_intestine	p.N617D (No)	GDSC	Nilotinib	23.11
SIDM00537	COREAD\|large_intestine	p.N617D (No)	GDSC	Dasatinib	9.6455
SIDM00537	COREAD\|large_intestine	p.A964V (No)	GDSC	Ponatinib	1.9526
SIDM00537	COREAD\|large_intestine	p.A964V (No)	GDSC	Nilotinib	5.2668
SIDM00537	COREAD\|large_intestine	p.A964V (No)	GDSC	Bosutinib	2.5114
SIDM00537	COREAD\|large_intestine	p.A964V (No)	GDSC	Nilotinib	23.11
SIDM00537	COREAD\|large_intestine	p.A964V (No)	GDSC	Dasatinib	9.6455
SIDM00374	DLBC\|B_cell_lymphoma	p.S1063C (No)	GDSC	Imatinib	26.8732
SIDM00374	DLBC\|B_cell_lymphoma	p.S1063C (No)	GDSC	Saracatinib	25.3576
SIDM00374	DLBC\|B_cell_lymphoma	p.S1063C (No)	GDSC	Dasatinib	1.0835
SIDM00374	DLBC\|B_cell_lymphoma	p.S1063C (No)	GDSC	Ponatinib	0.6336
SIDM00374	DLBC\|B_cell_lymphoma	p.S1063C (No)	GDSC	Nilotinib	15.4703
SIDM00374	DLBC\|B_cell_lymphoma	p.S1063C (No)	GDSC	Bosutinib	10.0496
SIDM00374	DLBC\|B_cell_lymphoma	p.S1063C (No)	GDSC	Nilotinib	20.431
SIDM00374	DLBC\|B_cell_lymphoma	p.S1063C (No)	GDSC	Dasatinib	1.8875
SIDM00410	ALL\|lymphoid_neoplasm_other	p.K908E (No)	GDSC	Imatinib	9.2701
SIDM00410	ALL\|lymphoid_neoplasm_other	p.K908E (No)	GDSC	Saracatinib	12.7268
SIDM00410	ALL\|lymphoid_neoplasm_other	p.K908E (No)	GDSC	Dasatinib	10.8097
SIDM00410	ALL\|lymphoid_neoplasm_other	p.K908E (No)	GDSC	Ponatinib	0.1843
SIDM00410	ALL\|lymphoid_neoplasm_other	p.K908E (No)	GDSC	Nilotinib	2.4803
SIDM00410	ALL\|lymphoid_neoplasm_other	p.K908E (No)	GDSC	Bosutinib	21.8578
SIDM00410	ALL\|lymphoid_neoplasm_other	p.K908E (No)	GDSC	Nilotinib	22.911
SIDM00410	ALL\|lymphoid_neoplasm_other	p.K908E (No)	GDSC	Dasatinib	3.503
SIDM00920	BRCA\|breast	p.P829L (No)	GDSC	Ponatinib	8.7607
SIDM00920	BRCA\|breast	p.P829L (No)	GDSC	Nilotinib	13.2045
SIDM00920	BRCA\|breast	p.P829L (No)	GDSC	Bosutinib	25.4631
SIDM00920	BRCA\|breast	p.P829L (No)	GDSC	Nilotinib	10.756
SIDM00920	BRCA\|breast	p.P829L (No)	GDSC	Dasatinib	19.827
SIDM00796	UNCLASSIFIED\|head_and_neck	p.R608H (No)	GDSC	Imatinib	27.7885
SIDM00796	UNCLASSIFIED\|head_and_neck	p.R608H (No)	GDSC	Saracatinib	14.093
SIDM00796	UNCLASSIFIED\|head_and_neck	p.R608H (No)	GDSC	Dasatinib	1.9569
SIDM00796	UNCLASSIFIED\|head_and_neck	p.R608H (No)	GDSC	Ponatinib	1.2656
SIDM00796	UNCLASSIFIED\|head_and_neck	p.R608H (No)	GDSC	Nilotinib	28.7699
SIDM00796	UNCLASSIFIED\|head_and_neck	p.R608H (No)	GDSC	Bosutinib	6.4408
SIDM00796	UNCLASSIFIED\|head_and_neck	p.R608H (No)	GDSC	Nilotinib	30.219
SIDM00796	UNCLASSIFIED\|head_and_neck	p.R608H (No)	GDSC	Dasatinib	4.6012

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: EHRDTTDVPEM

Degron related mutations and impact score

Drug responses associated with ABL1 mutations

All proteins holding degron of EHRDTTDVPEM

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P00519	Tyrosine-protein kinase ABL1	DEG_COP1_1	540:550	EHRDTTDVPEM	COP1	0.8875	More...