DegronMD

Uniprot ID: Q8IVF2

Source protein: Protein AHNAK2

Source gene: AHNAK2

Class: DEG_COP1_1

Location: 3540:3550

E3 ligase: COP1

DEGRON score: 0.9427

ASA_SCORE: 79.7636

COIL: 0.779

CONS_SCORE: 0.3688

DSS_SCORE: 0.437

HELIX: 0.1428

FCONS_SCORE: 0.7929

RIG_SCORE: 0.7051

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V3535G	TCGA-66-2756	LUSC	TCGA	ELLEGPVPEGA	DEG_COP1_1	0.1944
p.V3535G	TCGA-DO-A1K0	THCA	TCGA	ELLEGPVPEGA	DEG_COP1_1	0.1944
p.V3535G	DO27128	LUSC	ICGC	ELLEGPVPEGA	DEG_COP1_1	0.1944
p.V3535G	DO40723	THCA	ICGC	ELLEGPVPEGA	DEG_COP1_1	0.1944
p.G3551S	TCGA-AA-A010	COAD	TCGA	ELLEGPVPEGA	DEG_COP1_1	0.3056
p.G3551S	TCGA-B5-A11Y	UCEC	TCGA	ELLEGPVPEGA	DEG_COP1_1	0.3056
p.G3551S	DO40889	UCEC	ICGC	ELLEGPVPEGA	DEG_COP1_1	0.3056
p.G3551S	SIDM00290	Gastric Carcinoma	GDSC	ELLEGPVPEGA	DEG_COP1_1	0.3056
p.G3551S	ACH-000847	Gastric Cancer	CCLE	ELLEGPVPEGA	DEG_COP1_1	0.3056
p.G3551S	HGC-27	stomach	COSMIC	ELLEGPVPEGA	DEG_COP1_1	0.3056
p.E3560D	TCGA-EO-A22R	UCEC	TCGA	ELLEGPVPEGA	DEG_COP1_1	0.0556
p.E3560D	DO42713	UCEC	ICGC	ELLEGPVPEGA	DEG_COP1_1	0.0556
p.P3557H	TCGA-EY-A1GU	UCEC	TCGA	ELLEGPVPEGA	DEG_COP1_1	0.1389
p.P3557H	DO41518	UCEC	ICGC	ELLEGPVPEGA	DEG_COP1_1	0.1389
p.G3554E	SIDM02058	Esophageal Carcinoma	GDSC	ELLEGPVPEGA	DEG_COP1_1	0.2222
p.G3544C	SIDM01156	Small Cell Lung Carcinoma	GDSC	ELLEGPVPEGA	DEG_COP1_1	0.6489
p.G3544C	ACH-000890	Lung Cancer	CCLE	ELLEGPVPEGA	DEG_COP1_1	0.6489
p.G3544C	SW1271	lung	COSMIC	ELLEGPVPEGA	DEG_COP1_1	0.6489
p.A3534T	SIDM01229	Neuroblastoma	GDSC	ELLEGPVPEGA	DEG_COP1_1	0.1667
p.A3534T	ACH-002217	Neuroblastoma	CCLE	ELLEGPVPEGA	DEG_COP1_1	0.1667
p.A3534T	BE2-M17	autonomic_ganglia	COSMIC	ELLEGPVPEGA	DEG_COP1_1	0.1667
p.G3554V	SIDM00774	Breast Carcinoma	GDSC	ELLEGPVPEGA	DEG_COP1_1	0.2222
p.V3546L	SIDM01393	Gastric Carcinoma	GDSC	ELLEGPVPEGA	DEG_COP1_1	0.6765
p.V3546M	SIDM01700	Hodgkin's Lymphoma	GDSC	ELLEGPVPEGA	DEG_COP1_1	0.7208
p.V3546M	ACH-000165	Non-Cancerous	CCLE	ELLEGPVPEGA	DEG_COP1_1	0.7208
p.V3539G	NCI-H727	lung	COSMIC	ELLEGPVPEGA	DEG_COP1_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IVF2	Protein AHNAK2	DEG_COP1_1	3540:3550	ELLEGPVPEGA	COP1	0.9427	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ELLEGPVPEGA

Degron related mutations and impact score

Drug responses associated with AHNAK2 mutations

All proteins holding degron of ELLEGPVPEGA