DegronMD

Uniprot ID: Q9H173

Source protein: Nucleotide exchange factor SIL1

Source gene: SIL1

Class: DEG_APCC_TPR_1

Location: 459:461

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5886

ASA_SCORE: 113.9

COIL: 0.6937

CONS_SCORE: 0.3707

DSS_SCORE: 0.6616

HELIX: 0.3107

FCONS_SCORE: 0.8695

RIG_SCORE: 0.8061

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G451S	SIDM00032	Bladder Carcinoma	GDSC	ELR	DEG_APCC_TPR_1	0.1111
p.S452C	SIDM00528	Breast Carcinoma	GDSC	ELR	DEG_APCC_TPR_1	0.1389
p.S452C	ACH-000934	Breast Cancer	CCLE	ELR	DEG_APCC_TPR_1	0.1389
p.S452C	MDA-MB-361	breast	COSMIC	ELR	DEG_APCC_TPR_1	0.1389
p.S459C	MDA-MB-361	breast	COSMIC	ELR	DEG_APCC_TPR_1	0.7541

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H173	Nucleotide exchange factor SIL1	DEG_APCC_TPR_1	459:461	ELR	APC,CDC20,FZR1	0.5886	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons