DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
ENDGYVPDV
Uniprot ID:
Q6IE81
Source protein:
Protein Jade-1
Source gene:
JADE1
Class:
DEG_COP1_1
Location:
799:807
E3 ligase:
COP1
DEGRON score:
0.9941
ASA_SCORE:
84.4222
COIL:
0.8679
CONS_SCORE:
0.4554
DSS_SCORE:
0.5969
HELIX:
0.0913
FCONS_SCORE:
1.0652
RIG_SCORE:
0.6891
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.S792N
TCGA-BG-A222
UCEC
TCGA
ENDGYVPDV
DEG_COP1_1
0.1389
p.S814N
SNU-407
large_intestine
COSMIC
ENDGYVPDV
DEG_COP1_1
0.1389
Drug responses associated with JADE1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of ENDGYVPDV
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q6IE81
Protein Jade-1
DEG_COP1_1
799:807
ENDGYVPDV
COP1
0.9941
More...