DegronMD

Uniprot ID: Q5T1R4

Source protein: Transcription factor HIVEP3

Source gene: HIVEP3

Class: DEG_COP1_1

Location: 759:767

E3 ligase: COP1

DEGRON score: 0.9048

ASA_SCORE: 96.2222

COIL: 0.953

CONS_SCORE: 0.3276

DSS_SCORE: 0.7567

HELIX: 0.0204

FCONS_SCORE: 0.836

RIG_SCORE: 0.5567

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F773L	TCGA-B5-A3FA	UCEC	TCGA	EPSKSVPSL	DEG_COP1_1	0.1667
p.F773L	DO52402	UCEC	ICGC	EPSKSVPSL	DEG_COP1_1	0.1667
p.T771M	TCGA-D1-A17U	UCEC	TCGA	EPSKSVPSL	DEG_COP1_1	0.2222
p.T771M	DO41887	UCEC	ICGC	EPSKSVPSL	DEG_COP1_1	0.2222
p.P760Q	DO229041	LICA	ICGC	EPSKSVPSL	DEG_COP1_1	0.5924
p.S761R	DO228894	LICA	ICGC	EPSKSVPSL	DEG_COP1_1	0.7427
p.S761R	SIDM00339	Non-Small Cell Lung Carcinoma	GDSC	EPSKSVPSL	DEG_COP1_1	0.7427
p.S761R	ACH-000787	Lung Cancer	CCLE	EPSKSVPSL	DEG_COP1_1	0.7427
p.S761R	LXF-289	lung	COSMIC	EPSKSVPSL	DEG_COP1_1	0.7427
p.P760S	DO46528	OV	ICGC	EPSKSVPSL	DEG_COP1_1	0.5641
p.G769E	DO229456	SKCA	ICGC	EPSKSVPSL	DEG_COP1_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5T1R4	Transcription factor HIVEP3	DEG_COP1_1	759:767	EPSKSVPSL	COP1	0.9048	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons