DegronMD

Uniprot ID: Q6ISB3

Source protein: Grainyhead-like protein 2 homolog

Source gene: GRHL2

Class: DEG_COP1_1

Location: 188:197

E3 ligase: COP1

DEGRON score: 0.9971

ASA_SCORE: 73.77

COIL: 0.7222

CONS_SCORE: 0.4358

DSS_SCORE: 0.3857

HELIX: 0.0841

FCONS_SCORE: 1.0922

RIG_SCORE: 0.7971

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P195A	TCGA-23-1121	OV	TCGA	EQTQYDVPSL	DEG_COP1_1	0.7503
p.P195A	DO28731	OV	ICGC	EQTQYDVPSL	DEG_COP1_1	0.7503
p.A198V	TCGA-90-A4ED	LUSC	TCGA	EQTQYDVPSL	DEG_COP1_1	0.3056
p.A198V	DO45482	LUSC	ICGC	EQTQYDVPSL	DEG_COP1_1	0.3056
p.A198V	SIDM00251	Gastric Carcinoma	GDSC	EQTQYDVPSL	DEG_COP1_1	0.3056
p.A198V	ACH-000949	Gastric Cancer	CCLE	EQTQYDVPSL	DEG_COP1_1	0.3056
p.A198V	TGBC11TKB	stomach	COSMIC	EQTQYDVPSL	DEG_COP1_1	0.3056
p.L204F	TCGA-A8-A06Z	BRCA	TCGA	EQTQYDVPSL	DEG_COP1_1	0.1389
p.L204F	DO4092	BRCA	ICGC	EQTQYDVPSL	DEG_COP1_1	0.1389
p.V194M	TCGA-AX-A1CE	UCEC	TCGA	EQTQYDVPSL	DEG_COP1_1	0.7208
p.V194M	TCGA-FI-A2D5	UCEC	TCGA	EQTQYDVPSL	DEG_COP1_1	0.7208
p.V194M	DO42280	UCEC	ICGC	EQTQYDVPSL	DEG_COP1_1	0.7208
p.V194M	DO41331	UCEC	ICGC	EQTQYDVPSL	DEG_COP1_1	0.7208
p.E181G	TCGA-FI-A2D0	UCEC	TCGA	EQTQYDVPSL	DEG_COP1_1	0.1389
p.E181G	DO43891	UCEC	ICGC	EQTQYDVPSL	DEG_COP1_1	0.1389
p.P195S	TCGA-GN-A8LK	SKCM	TCGA	EQTQYDVPSL	DEG_COP1_1	0.6752
p.P195S	DO51259	SKCM	ICGC	EQTQYDVPSL	DEG_COP1_1	0.6752
p.Q191K	DO231618	LINC	ICGC	EQTQYDVPSL	DEG_COP1_1	0.5833
p.R183Q	SIDM00334	Endometrial Carcinoma	GDSC	EQTQYDVPSL	DEG_COP1_1	0.1944
p.A202T	ACH-001610	Brain Cancer	CCLE	EQTQYDVPSL	DEG_COP1_1	0.1944
p.R193C	YT	haematopoietic_and_lymphoid_tissue	COSMIC	EQTQYDVPSL	DEG_COP1_1	0.8301
p.A207T	RCH-ACV	haematopoietic_and_lymphoid_tissue	COSMIC	EQTQYDVPSL	DEG_COP1_1	0.0556
p.A182V	TGBC11TKB	stomach	COSMIC	EQTQYDVPSL	DEG_COP1_1	0.1667
p.T195P	NCI-H2085	lung	COSMIC	EQTQYDVPSL	DEG_COP1_1	0.7031

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ISB3	Grainyhead-like protein 2 homolog	DEG_COP1_1	188:197	EQTQYDVPSL	COP1	0.9971	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons