DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
ERDILKEMF
Uniprot ID:
P42167
Source protein:
Lamina-associated polypeptide 2, isoforms beta/gamma
Source gene:
TMPO
Class:
DEG_APCC_DBOX_1
Location:
341:349
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9691
ASA_SCORE:
73.7889
COIL:
0.3299
CONS_SCORE:
0.6729
DSS_SCORE:
0.4834
HELIX:
0.646
FCONS_SCORE:
1.1685
RIG_SCORE:
0.8249
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with TMPO mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of ERDILKEMF
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P42167
Lamina-associated polypeptide 2, isoforms beta/gamma
DEG_APCC_DBOX_1
341:349
ERDILKEMF
APC,CDC20,FZR1
0.9691
More...