DegronMD

Uniprot ID: A6XGL0

Source protein: YjeF N-terminal domain-containing protein 3

Source gene: YJEFN3

Class: DEG_APCC_DBOX_1

Location: 15:23

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.968

ASA_SCORE: 83.3

COIL: 0.3209

CONS_SCORE: 0.0962

DSS_SCORE: 0.6383

HELIX: 0.6608

FCONS_SCORE: 1.0649

RIG_SCORE: 0.7617

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E14K	TCGA-BG-A222	UCEC	TCGA	ERHFLRALE	DEG_APCC_DBOX_1	0.3056
p.E14K	DO42977	UCEC	ICGC	ERHFLRALE	DEG_APCC_DBOX_1	0.3056
p.P12Q	DO227994	COCA	ICGC	ERHFLRALE	DEG_APCC_DBOX_1	0.25
p.M10V	DO222645	ESCA	ICGC	ERHFLRALE	DEG_APCC_DBOX_1	0.6389
p.S10L	DO233156	GACA	ICGC	ERHFLRALE	DEG_APCC_DBOX_1	0.6389
p.A5T	DO233234	GACA	ICGC	ERHFLRALE	DEG_APCC_DBOX_1	0.0556
p.S31L	DO16871	KIRC	ICGC	ERHFLRALE	DEG_APCC_DBOX_1	0.1111
p.A21T	DO50861	LICA	ICGC	ERHFLRALE	DEG_APCC_DBOX_1	0.6028
p.G14E	DO50970	LICA	ICGC	ERHFLRALE	DEG_APCC_DBOX_1	0.3056
p.M10I	DO231669	LINC	ICGC	ERHFLRALE	DEG_APCC_DBOX_1	0.6389
p.Q8H	DO26530	LUSC	ICGC	ERHFLRALE	DEG_APCC_DBOX_1	0.1389
p.G29V	DO26488	LUSC	ICGC	ERHFLRALE	DEG_APCC_DBOX_1	0.1667
p.Y33C	DO26469	LUSC	ICGC	ERHFLRALE	DEG_APCC_DBOX_1	0.0556
p.I19V	DO49085	LUSC	ICGC	ERHFLRALE	DEG_APCC_DBOX_1	0.7076
p.R23W	DO27532	LUSC	ICGC	ERHFLRALE	DEG_APCC_DBOX_1	0.8634
p.P9S	DO220859	MELA	ICGC	ERHFLRALE	DEG_APCC_DBOX_1	0.1667
p.P9S	ACH-000462	Leukemia	CCLE	ERHFLRALE	DEG_APCC_DBOX_1	0.1667
p.R28L	DO50669	ORCA	ICGC	ERHFLRALE	DEG_APCC_DBOX_1	0.1944
p.R33K	DO46623	PAAD	ICGC	ERHFLRALE	DEG_APCC_DBOX_1	0.0556
p.P12L	DO219317	PRAD	ICGC	ERHFLRALE	DEG_APCC_DBOX_1	0.25
p.K5N	DO219995	SARC	ICGC	ERHFLRALE	DEG_APCC_DBOX_1	0.0556
p.D30N	DO41020	UCEC	ICGC	ERHFLRALE	DEG_APCC_DBOX_1	0.1389
p.G6V	SIDM00749	Non-Small Cell Lung Carcinoma	GDSC	ERHFLRALE	DEG_APCC_DBOX_1	0.0833
p.G6V	ACH-000916	Lung Cancer	CCLE	ERHFLRALE	DEG_APCC_DBOX_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6XGL0	YjeF N-terminal domain-containing protein 3	DEG_APCC_DBOX_1	15:23	ERHFLRALE	APC,CDC20,FZR1	0.968	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons