DegronMD

Uniprot ID: Q96NL0

Source protein: RUN domain-containing protein 3B

Source gene: RUNDC3B

Class: DEG_APCC_DBOX_1

Location: 32:40

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6466

ASA_SCORE: 48.5111

COIL: 0.0097

CONS_SCORE: 0.7062

DSS_SCORE: 0.1192

HELIX: 0.9901

FCONS_SCORE: 1.2265

RIG_SCORE: 0.9007

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V31L	TCGA-A7-A13D	BRCA	TCGA	ERRNLITVC	DEG_APCC_DBOX_1	0.3056
p.V31L	DO1392	BRCA	ICGC	ERRNLITVC	DEG_APCC_DBOX_1	0.3056
p.N35D	TCGA-AA-3984	COAD	TCGA	ERRNLITVC	DEG_APCC_DBOX_1	0.5821
p.N35D	DO9002	COAD	ICGC	ERRNLITVC	DEG_APCC_DBOX_1	0.5821
p.S43Y	TCGA-D1-A17Q	UCEC	TCGA	ERRNLITVC	DEG_APCC_DBOX_1	0.25
p.S43Y	DO41903	UCEC	ICGC	ERRNLITVC	DEG_APCC_DBOX_1	0.25
p.R50L	TCGA-D3-A2JP	SKCM	TCGA	ERRNLITVC	DEG_APCC_DBOX_1	0.0556
p.R50L	TCGA-FS-A1ZB	SKCM	TCGA	ERRNLITVC	DEG_APCC_DBOX_1	0.0556
p.R50L	DO37886	SKCM	ICGC	ERRNLITVC	DEG_APCC_DBOX_1	0.0556
p.R50L	DO47407	SKCM	ICGC	ERRNLITVC	DEG_APCC_DBOX_1	0.0556
p.A30V	TCGA-D7-A4YV	STAD	TCGA	ERRNLITVC	DEG_APCC_DBOX_1	0.2778
p.A30V	DO47777	STAD	ICGC	ERRNLITVC	DEG_APCC_DBOX_1	0.2778
p.T46I	TCGA-EY-A215	UCEC	TCGA	ERRNLITVC	DEG_APCC_DBOX_1	0.1667
p.T46I	DO42665	UCEC	ICGC	ERRNLITVC	DEG_APCC_DBOX_1	0.1667
p.K45T	TCGA-LL-A8F5	BRCA	TCGA	ERRNLITVC	DEG_APCC_DBOX_1	0.3056
p.K45T	DO50068	BRCA	ICGC	ERRNLITVC	DEG_APCC_DBOX_1	0.3056
p.D49Y	DO233134	GACA	ICGC	ERRNLITVC	DEG_APCC_DBOX_1	0.0833
p.S23I	DO229038	LICA	ICGC	ERRNLITVC	DEG_APCC_DBOX_1	0.0833
p.C40F	DO46370	OV	ICGC	ERRNLITVC	DEG_APCC_DBOX_1	0.5996
p.S25R	DO227558	PACA	ICGC	ERRNLITVC	DEG_APCC_DBOX_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96NL0	RUN domain-containing protein 3B	DEG_APCC_DBOX_1	32:40	ERRNLITVC	APC,CDC20,FZR1	0.6466	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons