DegronMD

Uniprot ID: Q6NSJ2

Source protein: Pleckstrin homology-like domain family B member 3

Source gene: PHLDB3

Class: DEG_APCC_DBOX_1

Location: 318:326

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6741

ASA_SCORE: 103.8222

COIL: 0.3264

CONS_SCORE: 0.5611

DSS_SCORE: 0.395

HELIX: 0.6514

FCONS_SCORE: 1.0118

RIG_SCORE: 0.7736

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.C327Y	TCGA-BP-4976	KIRC	TCGA	ERSRLLELN	DEG_APCC_DBOX_1	0.3056
p.C327Y	DO17492	KIRC	ICGC	ERSRLLELN	DEG_APCC_DBOX_1	0.3056
p.A311S	DO233746	GACA	ICGC	ERSRLLELN	DEG_APCC_DBOX_1	0.1389
p.A314V	DO228194	LICA	ICGC	ERSRLLELN	DEG_APCC_DBOX_1	0.2222
p.G334R	SIDM00565	Oral Cavity Carcinoma	GDSC	ERSRLLELN	DEG_APCC_DBOX_1	0.1111
p.G334R	SIDM01172	Acute Myeloid Leukemia	GDSC	ERSRLLELN	DEG_APCC_DBOX_1	0.1111
p.G334R	SIDM01762	Esophageal Squamous Cell Carcinoma	GDSC	ERSRLLELN	DEG_APCC_DBOX_1	0.1111
p.G334R	THP-1	haematopoietic_and_lymphoid_tissue	COSMIC	ERSRLLELN	DEG_APCC_DBOX_1	0.1111
p.G334R	OSC-20	upper_aerodigestive_tract	COSMIC	ERSRLLELN	DEG_APCC_DBOX_1	0.1111
p.R321W	SIDM00381	Cervical Carcinoma	GDSC	ERSRLLELN	DEG_APCC_DBOX_1	0.7523
p.R321W	ACH-001020	Rhabdoid	CCLE	ERSRLLELN	DEG_APCC_DBOX_1	0.7523
p.R321W	ACH-002020	Cervical Cancer	CCLE	ERSRLLELN	DEG_APCC_DBOX_1	0.7523
p.R321W	SKG-IIIa	cervix	COSMIC	ERSRLLELN	DEG_APCC_DBOX_1	0.7523
p.N326S	SIDM01518	Oral Cavity Carcinoma	GDSC	ERSRLLELN	DEG_APCC_DBOX_1	0.5958

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6NSJ2	Pleckstrin homology-like domain family B member 3	DEG_APCC_DBOX_1	318:326	ERSRLLELN	APC,CDC20,FZR1	0.6741	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons