DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
ERYPLPTVL
Uniprot ID:
A6NJV1
Source protein:
Protein FAM166C
Source gene:
FAM166C
Class:
DEG_APCC_DBOX_1
Location:
146:154
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.7058
ASA_SCORE:
83.4667
COIL:
0.8409
CONS_SCORE:
0.4351
DSS_SCORE:
0.3044
HELIX:
0.1253
FCONS_SCORE:
0.8819
RIG_SCORE:
0.7694
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.H164Y
SIDM00740
Squamous Cell Lung Carcinoma
GDSC
ERYPLPTVL
DEG_APCC_DBOX_1
0.0556
Drug responses associated with FAM166C mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of ERYPLPTVL
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
A6NJV1
Protein FAM166C
DEG_APCC_DBOX_1
146:154
ERYPLPTVL
APC,CDC20,FZR1
0.7058
More...