DegronMD

Uniprot ID: O43866

Source protein: CD5 antigen-like

Source gene: CD5L

Class: DEG_COP1_1

Location: 128:138

E3 ligase: COP1

DEGRON score: 0.9545

ASA_SCORE: 67.5909

COIL: 0.7679

CONS_SCORE: 0.5736

DSS_SCORE: 0.5609

HELIX: 0.0494

FCONS_SCORE: 0.8147

RIG_SCORE: 0.6441

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D119Y	TCGA-AA-A010	COAD	TCGA	ESSFSPVPEGV	DEG_COP1_1	0.0833
p.P133Q	TCGA-AC-A2BK	BRCA	TCGA	ESSFSPVPEGV	DEG_COP1_1	0.5924
p.P133Q	DO1328	BRCA	ICGC	ESSFSPVPEGV	DEG_COP1_1	0.5924
p.P133Q	DO23276	LINC	ICGC	ESSFSPVPEGV	DEG_COP1_1	0.5924
p.F131L	TCGA-AX-A05Z	UCEC	TCGA	ESSFSPVPEGV	DEG_COP1_1	0.587
p.F131L	DO228328	BRCA	ICGC	ESSFSPVPEGV	DEG_COP1_1	0.587
p.F131L	DO40884	UCEC	ICGC	ESSFSPVPEGV	DEG_COP1_1	0.587
p.F131S	TCGA-BR-8368	STAD	TCGA	ESSFSPVPEGV	DEG_COP1_1	0.6871
p.F131S	DO47981	STAD	ICGC	ESSFSPVPEGV	DEG_COP1_1	0.6871
p.G137S	TCGA-D9-A6EC	SKCM	TCGA	ESSFSPVPEGV	DEG_COP1_1	0.6993
p.G137S	DO50291	SKCM	ICGC	ESSFSPVPEGV	DEG_COP1_1	0.6993
p.P133T	TCGA-DF-A2KN	UCEC	TCGA	ESSFSPVPEGV	DEG_COP1_1	0.5919
p.P133T	DO23276	LINC	ICGC	ESSFSPVPEGV	DEG_COP1_1	0.5919
p.P133T	DO223282	UCEC	ICGC	ESSFSPVPEGV	DEG_COP1_1	0.5919
p.A120D	TCGA-DU-6392	LGG	TCGA	ESSFSPVPEGV	DEG_COP1_1	0.1111
p.A120D	DO22237	LGG	ICGC	ESSFSPVPEGV	DEG_COP1_1	0.1111
p.S132F	TCGA-EE-A29E	SKCM	TCGA	ESSFSPVPEGV	DEG_COP1_1	0.6871
p.S132F	DO37831	SKCM	ICGC	ESSFSPVPEGV	DEG_COP1_1	0.6871
p.G137D	TCGA-EE-A29P	SKCM	TCGA	ESSFSPVPEGV	DEG_COP1_1	0.7198
p.G137D	DO37916	SKCM	ICGC	ESSFSPVPEGV	DEG_COP1_1	0.7198
p.S123L	TCGA-EE-A2GT	SKCM	TCGA	ESSFSPVPEGV	DEG_COP1_1	0.1944
p.S123L	TCGA-EE-A2ML	SKCM	TCGA	ESSFSPVPEGV	DEG_COP1_1	0.1944
p.S123L	TCGA-KM-8442	KICH	TCGA	ESSFSPVPEGV	DEG_COP1_1	0.1944
p.S123L	DO220359	KICH	ICGC	ESSFSPVPEGV	DEG_COP1_1	0.1944
p.S123L	DO220902	MELA	ICGC	ESSFSPVPEGV	DEG_COP1_1	0.1944
p.S123L	DO222429	MELA	ICGC	ESSFSPVPEGV	DEG_COP1_1	0.1944
p.S123L	DO37408	SKCM	ICGC	ESSFSPVPEGV	DEG_COP1_1	0.1944
p.S123L	DO37946	SKCM	ICGC	ESSFSPVPEGV	DEG_COP1_1	0.1944
p.L140M	TCGA-VP-A87C	PRAD	TCGA	ESSFSPVPEGV	DEG_COP1_1	0.2778
p.L140M	DO51384	PRAD	ICGC	ESSFSPVPEGV	DEG_COP1_1	0.2778
p.P133A	DO225034	BRCA	ICGC	ESSFSPVPEGV	DEG_COP1_1	0.6392
p.P133A	DO227795	BRCA	ICGC	ESSFSPVPEGV	DEG_COP1_1	0.6392
p.P144R	DO225154	BRCA	ICGC	ESSFSPVPEGV	DEG_COP1_1	0.1667
p.P144H	DO228971	LICA	ICGC	ESSFSPVPEGV	DEG_COP1_1	0.1667
p.G137V	DO224563	LUSC	ICGC	ESSFSPVPEGV	DEG_COP1_1	0.6421
p.V134F	DO231132	LUSC	ICGC	ESSFSPVPEGV	DEG_COP1_1	0.7068
p.C124S	DO229245	THCA	ICGC	ESSFSPVPEGV	DEG_COP1_1	0.2222
p.A120V	SIDM00216	Colorectal Carcinoma	GDSC	ESSFSPVPEGV	DEG_COP1_1	0.1111
p.A120V	ACH-000989	Colon/Colorectal Cancer	CCLE	ESSFSPVPEGV	DEG_COP1_1	0.1111
p.A120V	SNU-175	large_intestine	COSMIC	ESSFSPVPEGV	DEG_COP1_1	0.1111
p.A141D	SIDM00104	Mesothelioma	GDSC	ESSFSPVPEGV	DEG_COP1_1	0.25
p.A141D	ACH-002123	Lung Cancer	CCLE	ESSFSPVPEGV	DEG_COP1_1	0.25
p.A141D	H2369	pleura	COSMIC	ESSFSPVPEGV	DEG_COP1_1	0.25
p.P135S	SIDM00784	Glioma	GDSC	ESSFSPVPEGV	DEG_COP1_1	0.6752
p.P135S	ACH-000126	Brain Cancer	CCLE	ESSFSPVPEGV	DEG_COP1_1	0.6752
p.V134I	SIDM01750	Melanoma	GDSC	ESSFSPVPEGV	DEG_COP1_1	0.7076
p.V134I	ACH-000801	Skin Cancer	CCLE	ESSFSPVPEGV	DEG_COP1_1	0.7076

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ESSFSPVPEGV

Degron related mutations and impact score

Drug responses associated with CD5L mutations

All proteins holding degron of ESSFSPVPEGV

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43866	CD5 antigen-like	DEG_COP1_1	128:138	ESSFSPVPEGV	COP1	0.9545	More...