DegronMD

Uniprot ID: Q9BXT5

Source protein: Testis-expressed protein 15

Source gene: TEX15

Class: DEG_COP1_1

Location: 2499:2508

E3 ligase: COP1

DEGRON score: 0.9953

ASA_SCORE: 67.11

COIL: 0.6777

CONS_SCORE: 0.5944

DSS_SCORE: 0.2896

HELIX: 0.1408

FCONS_SCORE: 1.411

RIG_SCORE: 0.7806

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D2501N	TCGA-55-6987	LUAD	TCGA	ETDVSLVPDA	DEG_COP1_1	0.6932
p.D2501N	DO25379	LUAD	ICGC	ETDVSLVPDA	DEG_COP1_1	0.6932
p.A2508V	TCGA-AA-3715	COAD	TCGA	ETDVSLVPDA	DEG_COP1_1	0.5825
p.A2508V	TCGA-F4-6856	COAD	TCGA	ETDVSLVPDA	DEG_COP1_1	0.5825
p.A2508V	DO8018	COAD	ICGC	ETDVSLVPDA	DEG_COP1_1	0.5825
p.A2508V	DO9114	COAD	ICGC	ETDVSLVPDA	DEG_COP1_1	0.5825
p.A2508V	ACH-000932	Gastric Cancer	CCLE	ETDVSLVPDA	DEG_COP1_1	0.5825
p.A2508V	NCI-SNU-1	stomach	COSMIC	ETDVSLVPDA	DEG_COP1_1	0.5825
p.D2501H	TCGA-D8-A1JA	BRCA	TCGA	ETDVSLVPDA	DEG_COP1_1	0.7688
p.D2501H	DO2819	BRCA	ICGC	ETDVSLVPDA	DEG_COP1_1	0.7688
p.L2504I	TCGA-EO-A22X	UCEC	TCGA	ETDVSLVPDA	DEG_COP1_1	0.6063
p.L2504I	DO222762	COCA	ICGC	ETDVSLVPDA	DEG_COP1_1	0.6063
p.L2504I	DO43907	UCEC	ICGC	ETDVSLVPDA	DEG_COP1_1	0.6063
p.S2491F	DO220886	MELA	ICGC	ETDVSLVPDA	DEG_COP1_1	0.1111
p.S2491F	DO229459	SKCA	ICGC	ETDVSLVPDA	DEG_COP1_1	0.1111
p.V2505I	SIDM00087	Plasma Cell Myeloma	GDSC	ETDVSLVPDA	DEG_COP1_1	0.7076
p.S2494A	SIDM00475	Ovarian Carcinoma	GDSC	ETDVSLVPDA	DEG_COP1_1	0.1944
p.S2494Y	SIDM00118	Colorectal Carcinoma	GDSC	ETDVSLVPDA	DEG_COP1_1	0.1944
p.S2494Y	HCC2998	large_intestine	COSMIC	ETDVSLVPDA	DEG_COP1_1	0.1944
p.V2515A	SIDM01582	Gastric Carcinoma	GDSC	ETDVSLVPDA	DEG_COP1_1	0.1389
p.V2515A	SIDM01511	Gastric Carcinoma	GDSC	ETDVSLVPDA	DEG_COP1_1	0.1389
p.D2501Y	ACH-000345	Neuroblastoma	CCLE	ETDVSLVPDA	DEG_COP1_1	0.7325
p.D2501Y	KP-N-RT-BM-1	autonomic_ganglia	COSMIC	ETDVSLVPDA	DEG_COP1_1	0.7325
p.L2493I	ACH-000901	Lung Cancer	CCLE	ETDVSLVPDA	DEG_COP1_1	0.1667
p.I2496T	ACH-001608	Brain Cancer	CCLE	ETDVSLVPDA	DEG_COP1_1	0.25
p.S2498Y	HCC2998	large_intestine	COSMIC	ETDVSLVPDA	DEG_COP1_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BXT5	Testis-expressed protein 15	DEG_COP1_1	2499:2508	ETDVSLVPDA	COP1	0.9953	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ETDVSLVPDA

Degron related mutations and impact score

Drug responses associated with TEX15 mutations

All proteins holding degron of ETDVSLVPDA