DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
ETTPSPVPTA
Uniprot ID:
P98088
Source protein:
Mucin-5AC
Source gene:
MUC5AC
Class:
DEG_COP1_1
Location:
2633:2642
E3 ligase:
COP1
DEGRON score:
0.7371
ASA_SCORE:
95.63
COIL:
0.9376
CONS_SCORE:
0.2754
DSS_SCORE:
0.7072
HELIX:
0.0139
FCONS_SCORE:
0.9175
RIG_SCORE:
0.5993
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P2632S
SIDM00329
Hodgkin's Lymphoma
GDSC
ETTPSPVPTA
DEG_COP1_1
0.3056
Drug responses associated with MUC5AC mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of ETTPSPVPTA
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P98088
Mucin-5AC
DEG_COP1_1
2633:2642
ETTPSPVPTA
COP1
0.7371
More...