DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
ETVPVPSV
Uniprot ID:
Q9H4G8
Source protein:
Putative DPH3 homolog B
Source gene:
DPH3P1
Class:
DEG_COP1_1
Location:
68:75
E3 ligase:
COP1
DEGRON score:
0.7187
ASA_SCORE:
90.4625
COIL:
0.9254
CONS_SCORE:
0.2717
DSS_SCORE:
0.4337
HELIX:
0.0158
FCONS_SCORE:
0.6324
RIG_SCORE:
0.7832
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with DPH3P1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of ETVPVPSV
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9H4G8
Putative DPH3 homolog B
DEG_COP1_1
68:75
ETVPVPSV
COP1
0.7187
More...