DegronMD

Uniprot ID: Q7L5N1

Source protein: COP9 signalosome complex subunit 6

Source gene: COPS6

Class: DEG_COP1_1

Location: 21:30

E3 ligase: COP1

DEGRON score: 0.7608

ASA_SCORE: 77.4

COIL: 0.7192

CONS_SCORE: 0.5922

DSS_SCORE: 0.189

HELIX: 0.2273

FCONS_SCORE: 1.3278

RIG_SCORE: 0.8224

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V22G	DO46542	OV	ICGC	EVDAAVVPSV	DEG_COP1_1	0.6421
p.V22G	DO229084	THCA	ICGC	EVDAAVVPSV	DEG_COP1_1	0.6421
p.C33S	SIDM01519	Head and Neck Carcinoma	GDSC	EVDAAVVPSV	DEG_COP1_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7L5N1	COP9 signalosome complex subunit 6	DEG_COP1_1	21:30	EVDAAVVPSV	COP1	0.7608	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons