DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
EVETRAVPSP
Uniprot ID:
Q96JP2
Source protein:
Unconventional myosin-XVB
Source gene:
MYO15B
Class:
DEG_COP1_1
Location:
1017:1026
E3 ligase:
COP1
DEGRON score:
0.7608
ASA_SCORE:
113.34
COIL:
0.8606
CONS_SCORE:
0.2844
DSS_SCORE:
0.8304
HELIX:
0.1313
FCONS_SCORE:
0.9309
RIG_SCORE:
0.595
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.E1019K
NCI-H446
lung
COSMIC
EVETRAVPSP
DEG_COP1_1
0.591
p.P1016L
LIM1215
large_intestine
COSMIC
EVETRAVPSP
DEG_COP1_1
0.3056
Drug responses associated with MYO15B mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of EVETRAVPSP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q96JP2
Unconventional myosin-XVB
DEG_COP1_1
1017:1026
EVETRAVPSP
COP1
0.7608
More...