DegronMD

Uniprot ID: Q9BQI3

Source protein: Eukaryotic translation initiation factor 2-alpha kinase 1

Source gene: EIF2AK1

Class: DEG_SCF_SKP2-CKS1_1

Location: 281:288

E3 ligase: SKP2,CSK1

DEGRON score: 0.9969

ASA_SCORE: 81.1125

COIL: 0.7594

CONS_SCORE: 0.3289

DSS_SCORE: 0.638

HELIX: 0.1663

FCONS_SCORE: 0.9864

RIG_SCORE: 0.6767

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R291C	TCGA-50-6594	LUAD	TCGA	FAEPTPEK	DEG_SCF_SKP2-CKS1_1	0.25
p.E294K	TCGA-AN-A046	BRCA	TCGA	FAEPTPEK	DEG_SCF_SKP2-CKS1_1	0.1667
p.E294K	TCGA-GD-A3OP	BLCA	TCGA	FAEPTPEK	DEG_SCF_SKP2-CKS1_1	0.1667
p.R291H	TCGA-AP-A0LM	UCEC	TCGA	FAEPTPEK	DEG_SCF_SKP2-CKS1_1	0.25
p.S277A	TCGA-B5-A1MR	UCEC	TCGA	FAEPTPEK	DEG_SCF_SKP2-CKS1_1	0.2222
p.S278F	TCGA-EE-A29N	SKCM	TCGA	FAEPTPEK	DEG_SCF_SKP2-CKS1_1	0.25
p.S276C	TCGA-UF-A7J9	HNSC	TCGA	FAEPTPEK	DEG_SCF_SKP2-CKS1_1	0.6389
p.A286T	DO1608	BRCA	ICGC	FAEPTPEK	DEG_SCF_SKP2-CKS1_1	0.7139
p.R279W	DO233737	GACA	ICGC	FAEPTPEK	DEG_SCF_SKP2-CKS1_1	0.2778
p.R277W	DO233889	GACA	ICGC	FAEPTPEK	DEG_SCF_SKP2-CKS1_1	0.2222
p.T296A	DO15006	HNSC	ICGC	FAEPTPEK	DEG_SCF_SKP2-CKS1_1	0.1111
p.N275K	DO228985	LICA	ICGC	FAEPTPEK	DEG_SCF_SKP2-CKS1_1	0.6111
p.R277L	DO230982	LUSC	ICGC	FAEPTPEK	DEG_SCF_SKP2-CKS1_1	0.2222
p.R277L	DO224613	LUSC	ICGC	FAEPTPEK	DEG_SCF_SKP2-CKS1_1	0.2222
p.E284K	DO219136	LUSC	ICGC	FAEPTPEK	DEG_SCF_SKP2-CKS1_1	0.7022
p.S285Y	DO232224	PBCA	ICGC	FAEPTPEK	DEG_SCF_SKP2-CKS1_1	0.712
p.P288S	DO47419	SKCM	ICGC	FAEPTPEK	DEG_SCF_SKP2-CKS1_1	0.6752
p.E273K	DO43154	UCEC	ICGC	FAEPTPEK	DEG_SCF_SKP2-CKS1_1	0.1111
p.E273K	DO41572	UCEC	ICGC	FAEPTPEK	DEG_SCF_SKP2-CKS1_1	0.1111
p.E273K	DO42608	UCEC	ICGC	FAEPTPEK	DEG_SCF_SKP2-CKS1_1	0.1111
p.E280D	DO42665	UCEC	ICGC	FAEPTPEK	DEG_SCF_SKP2-CKS1_1	0.3056
p.S276R	SIDM00938	Breast Carcinoma	GDSC	FAEPTPEK	DEG_SCF_SKP2-CKS1_1	0.6389
p.S276R	ACH-000902	Breast Cancer	CCLE	FAEPTPEK	DEG_SCF_SKP2-CKS1_1	0.6389
p.S276R	CAL-148	breast	COSMIC	FAEPTPEK	DEG_SCF_SKP2-CKS1_1	0.6389
p.T297A	SIDM01013	B-Cell Non-Hodgkin's Lymphoma	GDSC	FAEPTPEK	DEG_SCF_SKP2-CKS1_1	0.5278
p.T297A	ACH-000106	Lymphoma	CCLE	FAEPTPEK	DEG_SCF_SKP2-CKS1_1	0.5278
p.T297A	JVM-2	haematopoietic_and_lymphoid_tissue	COSMIC	FAEPTPEK	DEG_SCF_SKP2-CKS1_1	0.5278

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: FAEPTPEK

Degron related mutations and impact score

Drug responses associated with EIF2AK1 mutations

All proteins holding degron of FAEPTPEK

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BQI3	Eukaryotic translation initiation factor 2-alpha kinase 1	DEG_SCF_SKP2-CKS1_1	281:288	FAEPTPEK	SKP2,CSK1	0.9969	More...