DegronMD

Uniprot ID: Q96C92

Source protein: Endosome-associated-trafficking regulator 1

Source gene: ENTR1

Class: LIG_APCC_ABBA_1

Location: 252:257

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5563

ASA_SCORE: 81.6167

COIL: 0.5887

CONS_SCORE: 0.357

DSS_SCORE: 0.5146

HELIX: 0.3418

FCONS_SCORE: 0.8758

RIG_SCORE: 0.68

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S249C	SIDM01302	Esophageal Carcinoma	GDSC	FAVHGE	LIG_APCC_ABBA_1	0.6944
p.A253V	SIDM00082	Melanoma	GDSC	FAVHGE	LIG_APCC_ABBA_1	0.5825
p.A253V	SK-MEL-2	skin	COSMIC	FAVHGE	LIG_APCC_ABBA_1	0.5825
p.R262K	SIDM01743	Melanoma	GDSC	FAVHGE	LIG_APCC_ABBA_1	0.1944
p.A250T	SNU-1040	large_intestine	COSMIC	FAVHGE	LIG_APCC_ABBA_1	0.2778
p.S249L	SNU-407	large_intestine	COSMIC	FAVHGE	LIG_APCC_ABBA_1	0.6944
p.R264W	SNU-175	large_intestine	COSMIC	FAVHGE	LIG_APCC_ABBA_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96C92	Endosome-associated-trafficking regulator 1	LIG_APCC_ABBA_1	252:257	FAVHGE	APC,CDC20,FZR1	0.5563	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons