DegronMD

Uniprot ID: P47712

Source protein: Cytosolic phospholipase A2

Source gene: PLA2G4A

Class: LIG_APCC_ABBA_1

Location: 668:673

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9693

ASA_SCORE: 58.5167

COIL: 0.7358

CONS_SCORE: 0.4169

DSS_SCORE: 0.4826

HELIX: 0.1175

FCONS_SCORE: 1.0175

RIG_SCORE: 0.8116

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F678C	TCGA-28-1747	GBM	TCGA	FDIFDD	LIG_APCC_ABBA_1	0.1944
p.F678C	DO13096	GBM	ICGC	FDIFDD	LIG_APCC_ABBA_1	0.1944
p.P674T	TCGA-A5-A2K3	UCEC	TCGA	FDIFDD	LIG_APCC_ABBA_1	0.3056
p.P674T	DO43899	UCEC	ICGC	FDIFDD	LIG_APCC_ABBA_1	0.3056
p.S679P	TCGA-CA-6717	COAD	TCGA	FDIFDD	LIG_APCC_ABBA_1	0.1667
p.S679P	DO8264	COAD	ICGC	FDIFDD	LIG_APCC_ABBA_1	0.1667
p.D669Y	TCGA-DD-A113	LIHC	TCGA	FDIFDD	LIG_APCC_ABBA_1	0.6214
p.D669Y	DO22920	LIHC	ICGC	FDIFDD	LIG_APCC_ABBA_1	0.6214
p.E658G	TCGA-E1-5303	LGG	TCGA	FDIFDD	LIG_APCC_ABBA_1	0.0556
p.E658G	DO22153	LGG	ICGC	FDIFDD	LIG_APCC_ABBA_1	0.0556
p.E664D	TCGA-E6-A1LX	UCEC	TCGA	FDIFDD	LIG_APCC_ABBA_1	0.2222
p.E664D	DO41020	UCEC	ICGC	FDIFDD	LIG_APCC_ABBA_1	0.2222
p.E662D	TCGA-EO-A22X	UCEC	TCGA	FDIFDD	LIG_APCC_ABBA_1	0.1667
p.E662D	DO43907	UCEC	ICGC	FDIFDD	LIG_APCC_ABBA_1	0.1667
p.D672V	DO228974	LICA	ICGC	FDIFDD	LIG_APCC_ABBA_1	0.6674
p.D667Y	DO229036	LICA	ICGC	FDIFDD	LIG_APCC_ABBA_1	0.3056
p.T659I	DO50738	LICA	ICGC	FDIFDD	LIG_APCC_ABBA_1	0.0833
p.F668V	DO228255	MALY	ICGC	FDIFDD	LIG_APCC_ABBA_1	0.5957

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P47712	Cytosolic phospholipase A2	LIG_APCC_ABBA_1	668:673	FDIFDD	APC,CDC20,FZR1	0.9693	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons