DegronMD

Uniprot ID: Q8WWQ8

Source protein: Stabilin-2

Source gene: STAB2

Class: LIG_APCC_ABBA_1

Location: 1232:1237

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.583

ASA_SCORE: 75.25

COIL: 0.6705

CONS_SCORE: 0.3611

DSS_SCORE: 0.0117

HELIX: 0.0513

FCONS_SCORE: 0.7612

RIG_SCORE: 0.9123

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F1232L	TCGA-A5-A0G2	UCEC	TCGA	FFLHND	LIG_APCC_ABBA_1	0.587
p.F1232L	DO41235	UCEC	ICGC	FFLHND	LIG_APCC_ABBA_1	0.587
p.Y1240D	TCGA-AA-3510	COAD	TCGA	FFLHND	LIG_APCC_ABBA_1	0.25
p.Y1240D	DO7783	COAD	ICGC	FFLHND	LIG_APCC_ABBA_1	0.25
p.S1231I	TCGA-B5-A1MX	UCEC	TCGA	FFLHND	LIG_APCC_ABBA_1	0.3056
p.S1231I	DO41999	UCEC	ICGC	FFLHND	LIG_APCC_ABBA_1	0.3056
p.F1229Y	TCGA-D3-A3C7	SKCM	TCGA	FFLHND	LIG_APCC_ABBA_1	0.25
p.F1229Y	DO47569	SKCM	ICGC	FFLHND	LIG_APCC_ABBA_1	0.25
p.S1231N	TCGA-E7-A3Y1	BLCA	TCGA	FFLHND	LIG_APCC_ABBA_1	0.3056
p.S1231N	DO528	BLCA	ICGC	FFLHND	LIG_APCC_ABBA_1	0.3056
p.S1227F	TCGA-FS-A4FC	SKCM	TCGA	FFLHND	LIG_APCC_ABBA_1	0.1944
p.S1227F	DO37762	SKCM	ICGC	FFLHND	LIG_APCC_ABBA_1	0.1944
p.N1242S	TCGA-H4-A2HQ	BLCA	TCGA	FFLHND	LIG_APCC_ABBA_1	0.1944
p.N1242S	DO522	BLCA	ICGC	FFLHND	LIG_APCC_ABBA_1	0.1944
p.Y1228S	SIDM00770	Small Cell Lung Carcinoma	GDSC	FFLHND	LIG_APCC_ABBA_1	0.2222
p.Y1228S	ACH-000559	Lung Cancer	CCLE	FFLHND	LIG_APCC_ABBA_1	0.2222
p.Y1228S	NCI-H1836	lung	COSMIC	FFLHND	LIG_APCC_ABBA_1	0.2222
p.S1231R	SIDM00466	Ovarian Carcinoma	GDSC	FFLHND	LIG_APCC_ABBA_1	0.3056
p.S1231R	ACH-000443	Ovarian Cancer	CCLE	FFLHND	LIG_APCC_ABBA_1	0.3056
p.S1231R	OVKATE	ovary	COSMIC	FFLHND	LIG_APCC_ABBA_1	0.3056
p.Y1240C	SIDM00839	Colorectal Carcinoma	GDSC	FFLHND	LIG_APCC_ABBA_1	0.25
p.Y1240C	ACH-000950	Colon/Colorectal Cancer	CCLE	FFLHND	LIG_APCC_ABBA_1	0.25
p.Y1240C	LoVo	large_intestine	COSMIC	FFLHND	LIG_APCC_ABBA_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WWQ8	Stabilin-2	LIG_APCC_ABBA_1	1232:1237	FFLHND	APC,CDC20,FZR1	0.583	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons