DegronMD

Uniprot ID: P48544

Source protein: G protein-activated inward rectifier potassium channel 4

Source gene: KCNJ5

Class: DEG_MDM2_SWIB_1

Location: 104:111

E3 ligase: MDM2

DEGRON score: 0.798

ASA_SCORE: 50

COIL: 0.0344

CONS_SCORE: 0.3319

DSS_SCORE: 0.0001

HELIX: 0.9588

FCONS_SCORE: 1.1966

RIG_SCORE: 1.2006

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V99F	TCGA-A5-A0G1	UCEC	TCGA	FGFIWWLI	DEG_MDM2_SWIB_1	0.1944
p.V99F	DO42472	UCEC	ICGC	FGFIWWLI	DEG_MDM2_SWIB_1	0.1944
p.W109L	TCGA-AJ-A3OJ	UCEC	TCGA	FGFIWWLI	DEG_MDM2_SWIB_1	0.5904
p.W109L	DO42753	UCEC	ICGC	FGFIWWLI	DEG_MDM2_SWIB_1	0.5904
p.L118Q	DO231992	LICA	ICGC	FGFIWWLI	DEG_MDM2_SWIB_1	0.1389
p.M95I	DO228978	LICA	ICGC	FGFIWWLI	DEG_MDM2_SWIB_1	0.0833
p.V121F	DO229019	LICA	ICGC	FGFIWWLI	DEG_MDM2_SWIB_1	0.0556
p.V121F	DO229032	LICA	ICGC	FGFIWWLI	DEG_MDM2_SWIB_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P48544	G protein-activated inward rectifier potassium channel 4	DEG_MDM2_SWIB_1	104:111	FGFIWWLI	MDM2	0.798	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons