DegronMD

Uniprot ID: O43683

Source protein: Mitotic checkpoint serine/threonine-protein kinase BUB1

Source gene: BUB1

Class: LIG_APCC_ABBA_1

Location: 527:532

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9953

ASA_SCORE: 68.9

COIL: 0.4625

CONS_SCORE: 0.3172

DSS_SCORE: 0.3174

HELIX: 0.3695

FCONS_SCORE: 1.2242

RIG_SCORE: 0.7857

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G533E	TCGA-06-5416	GBM	TCGA	FHVFED	LIG_APCC_ABBA_1	0.3056
p.G533E	DO10880	GBM	ICGC	FHVFED	LIG_APCC_ABBA_1	0.3056
p.H528N	TCGA-E6-A1LX	UCEC	TCGA	FHVFED	LIG_APCC_ABBA_1	0.6312
p.H528N	DO41020	UCEC	ICGC	FHVFED	LIG_APCC_ABBA_1	0.6312
p.S524P	DO228581	GACA	ICGC	FHVFED	LIG_APCC_ABBA_1	0.25
p.D532N	DO218554	ORCA	ICGC	FHVFED	LIG_APCC_ABBA_1	0.6932
p.P542S	Sarc9371	bone	COSMIC	FHVFED	LIG_APCC_ABBA_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43683	Mitotic checkpoint serine/threonine-protein kinase BUB1	LIG_APCC_ABBA_1	527:532	FHVFED	APC,CDC20,FZR1	0.9953	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons