DegronMD

Uniprot ID: Q7Z6A9

Source protein: B- and T-lymphocyte attenuator

Source gene: BTLA

Class: LIG_APCC_ABBA_1

Location: 98:103

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5198

ASA_SCORE: 21.9667

COIL: 0.1372

CONS_SCORE: 0.7838

DSS_SCORE: 0.1726

HELIX: 0.0027

FCONS_SCORE: 1.2562

RIG_SCORE: 0.9101

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L100V	TCGA-86-7954	LUAD	TCGA	FILHFE	LIG_APCC_ABBA_1	0.5654
p.L100V	DO23660	LUAD	ICGC	FILHFE	LIG_APCC_ABBA_1	0.5654
p.S96L	TCGA-LP-A5U2	CESC	TCGA	FILHFE	LIG_APCC_ABBA_1	0.2778
p.S96L	DO51610	CESC	ICGC	FILHFE	LIG_APCC_ABBA_1	0.2778
p.H101N	DO228976	LICA	ICGC	FILHFE	LIG_APCC_ABBA_1	0.7423
p.N94K	DO229022	LICA	ICGC	FILHFE	LIG_APCC_ABBA_1	0.2222
p.V105A	SIDM00980	Gastric Carcinoma	GDSC	FILHFE	LIG_APCC_ABBA_1	0.2778
p.V105A	ACH-000948	Gastric Cancer	CCLE	FILHFE	LIG_APCC_ABBA_1	0.2778
p.V105A	23132-87	stomach	COSMIC	FILHFE	LIG_APCC_ABBA_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z6A9	B- and T-lymphocyte attenuator	LIG_APCC_ABBA_1	98:103	FILHFE	APC,CDC20,FZR1	0.5198	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons