DegronMD

Uniprot ID: P42685

Source protein: Tyrosine-protein kinase FRK

Source gene: FRK

Class: DEG_APCC_TPR_1

Location: 503:505

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5263

ASA_SCORE: 117.5667

COIL: 0.6833

CONS_SCORE: 0.4416

DSS_SCORE: 0.7925

HELIX: 0.298

FCONS_SCORE: 0.8097

RIG_SCORE: 0.8169

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S496L	TCGA-V1-A9Z7	PRAD	TCGA	FIR	DEG_APCC_TPR_1	0.5833
p.T493I	SIDM00393	Gastric Carcinoma	GDSC	FIR	DEG_APCC_TPR_1	0.0556
p.T493I	ACH-001653	Gastric Cancer	CCLE	FIR	DEG_APCC_TPR_1	0.0556
p.T493I	SK-GT-2	stomach	COSMIC	FIR	DEG_APCC_TPR_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P42685	Tyrosine-protein kinase FRK	DEG_APCC_TPR_1	503:505	FIR	APC,CDC20,FZR1	0.5263	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons